A stage-specific cell-manipulation platform for inducing endothelialization on demand  

作　　者：Qilong Zhao Juan Wang Yunlong Wang Huanqing Cui Xuemin Du 

机构地区：[1]Institute of Biomedical&Health Engineering,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518035,China

出　　处：《National Science Review》2020年第3期629-643,共15页国家科学评论（英文版）

基　　金：the National Key R&D Program of China(2017YFA0701303);the National Natural Science Foundation of China(51903245);the Youth Innovation Promotion Association of CAS,CAS Key Laboratory of Health Informatics,Shenzhen Institutes of Advanced Technology,the Special Support Project for Outstanding Young Scholars of Guangdong Province(2015TQ01R292);Guangdong-Hong Kong Technology Cooperation Funding(2017A050506040);Shenzhen Science and Technology Innovation Committee(JCYJ20180507182051636,KQJSCX20180330170232019 and JCYJ20170413152640731);Shenzhen Peacock Plan(KQTD20170810160424889).

摘　　要：Endothelialization is of great significance for vascular remodeling,as well as for the success of implanted vascular grafts/stents in cardiovascular disease treatment.However,desirable endothelialization on synthetic biomaterials remains greatly challenging owing to extreme difficulty in offering dynamic guidance on endothelial cell(EC)functions resembling the native extracellular matrix-mediated effects.Here,we demonstrate a bilayer platform with near-infrared-triggered transformable topographies,which can alter the geometries and functions of human ECs by tunable topographical cues in a remote-controlled manner,yet cause no damage to the cell viability.The migration and the adhesion/spreading of human ECs are respectively promoted by the temporary anisotropic and permanent isotropic topographies of the platform in turn,which appropriately meet the requirements of stage-specific EC manipulation for endothelialization.In addition to the potential of promoting the development of a new generation of vascular grafts/stents enabling rapid endothelialization,this stage-specific cell-manipulation platform also holds promise in various biomedical fields,since the needs for stepwise control over different cell functions are common in wound healing and various tissue-regeneration processes.

关 键 词：BIOMATERIALS tissue engineering SHAPE-MEMORY polymer topographical conversion ENDOTHELIALIZATION 

分 类 号：R318.08[医药卫生—生物医学工程]