奥沙普秦的合成工艺研究  

Study on Synthesis Technology of Oxaprozin

作　　者：李公春[1] 李帅冰 LI Gongchun;LI Shuaibing(Key laboratory of Chemo/Biosensing and Detection,College of Chemistry and Chemical Engineering,Xuchang University,Xuchang 461000,China)

机构地区：[1]许昌学院化学化工学院,化学生物传感与检测重点实验室,河南许昌461000

出　　处：《许昌学院学报》2020年第2期62-64,共3页Journal of Xuchang University

基　　金：河南省高等学校重点科研项目(16B350003)。

摘　　要：以2-羟基-2-苯基苯乙酮为原料,与琥珀酸酐发生酯化反应形成单酯,单酯与醋酸铵环合得到奥沙普秦,研究了反应时间、温度、2-羟基-2-苯基苯乙酮与琥珀酸酐的物质的量比等条件对反应的影响.优化工艺下合成奥沙普秦的产率为64.78%,优化工艺产率高,易操作,适合工业化生产.Oxaprozin was synthesized taking 2-hydroxy-2-phenylacetophenone as the raw material by esterification of benzoin and succinic anhydride,then reaction with ammonium acetate.Experiments were performed to inspect reaction time,temperature,the ratio of 2-hydroxy-2-phenylacetophenone and succinic anhydride.The yield of oxaprozin is 64.78%under the optimized process which is easy to operate and suitable for industrial production.

关 键 词：非甾体抗炎药 奥沙普秦 合成工艺 

分 类 号：R914.5[医药卫生—药物化学]