功能多肽在肿瘤治疗中的应用及研究进展  

Application and Progress of Functional Peptides in Tumor Therapy

作　　者：刘传军 张驰 张先正[1] Chuanjun Liu;Chi Zhang;Xianzhang Zhang(Key Laboratory of Biomedical Polymers of Ministry of Education,College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,P.R.China)

机构地区：[1]武汉大学化学与分子科学学院,生物医用高分子材料教育部重点实验室,武汉430072

出　　处：《大学化学》2020年第3期1-7,共7页University Chemistry

基　　金：国家自然科学基金(201674084)。

摘　　要：多肽具有生物相容性好,功能多样化,生物体内响应性高及合成修饰方法简单易行等优点,已被广泛用于构建靶向药物传递系统。以具有靶向功能和刺激响应性的多肽为基础构建的药物传递系统,能够将药物定向地运送到肿瘤区域。药物传递系统到达肿瘤组织后,在肿瘤组织特殊微环境或外源刺激下,实现药物的精准释放。这种具有特异性肿瘤靶向和刺激响应型的多肽载体可以最大程度地提高药物的抗肿瘤效果,降低药物的毒副作用。本文简要介绍了常用的靶向多肽和刺激响应型多肽,并讨论了基于功能型多肽的药物载体在肿瘤治疗方面的应用。The peptide is intrinsically bioactive,biodegradable,biocompatible,and easy to undergo chemical modification,which makes it perfect for targeted drug delivery system(DDS).The DDSs based on targeting peptides and responsive peptides are able to deliver the drug into the tumor area.After the arrival of the carrier in tumor,the accurate release is realized upon the stimulus of special microenvironment of tumor tissue or the exogenous stimulus.The carrier based on peptides can reduce the toxic and side effects and improve to the most the anti-tumor effect of drug.The present paper outlined the several classes of peptides with targeting and stimulus-responsive properties,and summarized the research progress in applications of different types of functional peptides in tumor therapy.

关 键 词：多肽 肿瘤靶向 刺激响应性 药物传递 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]