乳腺切除预防BRCA1基因突变人群癌变研究进展  

Prophylactic mastectomy in patients with BRCA1 mutation

作　　者：汪操 司丕蕾 贾琳娇 刘继全 陈海军 鲁鹤臻 李文涛 WANG Cao;SI Pilei;JIA Linjiao;LIU Jiquan;CHEN Haijun;LU Hezhen;LI Wentao(Department of Breast Surgery,Zhengzhou University People's Hospital,Henan Provincial People's Hospital,Zhengzhou 150003,China)

机构地区：[1]郑州大学人民医院河南省人民医院乳腺外科,郑州450003

出　　处：《中华实用诊断与治疗杂志》2020年第4期420-422,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：河南省医学科技攻关计划项目(172102310097)。

摘　　要：BRCA1基因突变筛查能有效发现有乳腺癌家族史中的高风险患者。预防性乳腺切除术在降低乳腺癌发生风险方面的有效性已证实。国内也有一定规模的BRCA1基因突变筛查,但受多种因素影响,对突变携带人群的预防治疗,尤其是预防性乳腺切除术的应用仍较大程度落后于国外。本文就应用预防性乳腺切除术降低BRCA1基因突变携带者乳腺癌发生风险的研究进展作一综述。Screening for BRCA1 mutations can effectively identify high-risk patients with a family history of breast cancer.The effectiveness of prophylactic mastectomy for reducing the risk for breast cancer has been widely demonstrated.BRCA1 gene mutation screening has been also carried out in China,but due to a variety of factors,the prevention and treatment of mutation-carrying populations,especially the application of prophylactic mastectomy,still lags far behind abroad.This paper reviews the research progress of the efficacy of prophylactic mastectomy on reducing the risk for breast cancer in BRCA1 mutation carriers.

关 键 词：乳腺癌 BRCA1基因突变 预防性乳腺切除 

分 类 号：R737.9[医药卫生—肿瘤]