几种特殊情况下葡萄胎的管理  

Management of hydatidiform mole under certain special conditions

作　　者：李晓[1] 谢幸[1] Li Xiao;Xie Xing(Department of Gynecologic Oncology,Women's Hospital,School of Medicine,Zhejiang University,Hangzhou 310006,China)

机构地区：[1]浙江大学医学院附属妇产科医院妇科肿瘤科,杭州310006

出　　处：《中国医学前沿杂志（电子版）》2020年第5期18-22,共5页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：葡萄胎是一类良性妊娠滋养细胞疾病,但有进一步发展为妊娠滋养细胞肿瘤的可能,被视为癌前病变。葡萄胎分为完全性葡萄胎和部分性葡萄胎,二者遗传病理学特征和恶变概率均不相同,现代分子诊断技术为其准确诊断和亚分类带来了可能。本文对极早期葡萄胎的鉴别诊断、预防性化疗后的葡萄胎、葡萄胎清宫术后6个月血人绒毛膜促性腺激素持续异常、葡萄胎合并肺结节的处理、复发性葡萄胎等特殊情况下葡萄胎的管理做一综述,以期为葡萄胎的精准诊治提供借鉴。Hydatidiform mole is benign gestational trophoblastic disease,but may develop into gestational trophoblastic tumor.So,hydatidiform mole can be considered as precancerous.Hydatidiform mole can be divided into complete and partial hydatidiform mole with different genetic pathological features and malignant transformation probability.In order to provide evidence for accurate diagnosis and treatment of hydatidiform mole,present article reviewed the differential diagnosis of very early hydatidiform mole,hydatidiform mole after prophylactic chemotherapy,the management of hydatidiform mole with persistent elevated blood human chorionic gonadotropin or pulmonary nodules,and the management of recurrent hydatidiform mole.

关 键 词：完全性葡萄胎 部分性葡萄胎 人绒毛膜促性腺激素 P57 预防性化疗 双亲来源完全性葡萄胎 印记基因 

分 类 号：R737.33[医药卫生—肿瘤]