难治性精神分裂症患者血浆IL-6、CRP与其临床表型的关联研究  

Correlation between plasma IL-6 ,CRP and clinical phenotype in patients with treatment-resistant schizophrenia

作　　者：何云鹏[1] 周莉[1] 李智强[1] HE Yunpeng;ZHOU Li;LI Zhiqiang(Shandong Mental Health Center,Jinan 250014,China)

机构地区：[1]山东省精神卫生中心,山东济南250014

出　　处：《精神医学杂志》2019年第5期348-351,共4页Journal of Psychiatry

基　　金：山东省医药卫生科技发展计划项目(编号:2017WSB06)。

摘　　要：目的探讨难治性精神分裂症患者炎性因子白介素-6(IL-6)、C-反应蛋白(CRP)与其临床表型的关系。方法将62例难治性精神分裂症患者作为患者组,29名健康人群作为对照组,采用化学发光法检测两组血清中IL-6,采用免疫比浊法进行CRP的测定。采用阳性和阴性综合征量表(PANSS)评定精神分裂症患者的各临床表型。结果治疗8周后,患者组PANSS总分及阴性症状、情感症状评分均较基线时降低(P<0.05)。患者组的血清IL-6、CRP水平均高于对照组(P<0.05)。基线时,患者组血清IL-6水平与PANSS总分呈低度正相关(P<0.05),与阴性症状、认知症状均呈中度正相关(P<0.05)。治疗8周后,患者组血清IL-6水平与PANSS总分及阴性症状、情感症状均呈中度正相关(P<0.05)。在基线时,患者组血清CRP水平与PANSS攻击症状呈低度负相关(P<0.05)。结论难治性精神分裂症患者的细胞因子血清IL-6、CRP的水平与临床表型存在相关性,调节精神分裂症患者脑内细胞因子的IL-6、CRP水平也许可以改善精神分裂症患者的临床症状。Objective To explore the relationship between plasma IL-6,CRP and clinical phenotype in patients with treatment-resistant schizophrenia.Methods 62 patients with treatment-resistant schizophrenia(case group)and 29 healthy controls(control group)were selected and examined IL-6 by chemiluminescence assay and CRP by immunoturbidimetry.Positive and Negative Syndrome Scale(PANSS)was used to assess the clinical phenotype of schizophrenia.Results After 8-week treatment,the total score and factor scores of negative symptoms and affective symptoms in case group decreased significantly compared with those at baseline(P<0.05).Serum levels of IL-6 and CRP in case group were significantly higher than those in control group(P<0.05).At baseline,the serum level of IL-6 in case group showed a low positive correlation with the total score of PANSS(P<0.05),a moderate positive correlation with negative symptoms and cognitive symptoms(P<0.05).After 8-week treatment,the serum level of IL-6 was moderately positively correlated with the total score and factor scores of negative symptoms and affective symptoms of PANSS(P<0.05).At baseline,the CRP level in case group was lowly negatively correlated with aggressive symptoms of PANSS(P<0.05).Conclusion The levels of serum IL-6 and CRP in patients with treatment-resistant schizophrenia are correlated with the clinical phenotype.Regulating the levels of IL-6 and CRP in brain cytokines may improve the clinical symptoms in patients with schizophrenia.

关 键 词：难治性精神分裂症 IL-6 CRP 临床表型 

分 类 号：R749.3[医药卫生—神经病学与精神病学]