Caryophyllene-type sesquiterpenoids and α-furanones from the plant endophytic fungus Pestalotiopsis theae  

作　　者：GUO Long-Fang LIU Gao-Ran LIU Ling 

机构地区：[1]State Key Laboratory of Mycology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China [2]University of Chinese Academy of Sciences,Beijing 100039,China

出　　处：《Chinese Journal of Natural Medicines》2020年第4期261-267,共7页中国天然药物（英文版）

基　　金：the National Key R&D Program of China (No. 2018YFC0311002);the National Natural Science Foundation of China (Nos. 21772228 and21977113)。

摘　　要：Two new caryophyllene-type sesquiterpenoids, pestathenols A(1) and B(2) and one new α-furanone, pestatheranone A(6), along with five known compounds(3–5, 7 and 8) have been isolated from the crude extract of the plant endophytic fungus Pestalotiopsis theae. Their structures were unambiguously established by extensive spectroscopic analyses. The absolute configuration of the 5,6-diol moiety in 1 was assigned using Snatzke’s method. Compounds 1 and 2 showed weak cytotoxicity against HeLa cell line.

关 键 词：Structure elucidation SESQUITERPENOIDS Pestalotiopsis theae CYTOTOXICITY 

分 类 号：R284[医药卫生—中药学]