颅外动静脉畸形的诊治进展及其关键性问题  

Updates and critical issues in diagnosis and treatment of extracranial arteriovenous malformation

作　　者：林晓曦[1] 金云波[1] 华晨[1] 杨希[1] Lin Xiaoxi;Jin Yunbo;Hua Chen;Yang Xi(Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院整复外科,200011

出　　处：《中华整形外科杂志》2020年第4期347-354,共8页Chinese Journal of Plastic Surgery

基　　金：上海交通大学医学院临床研究中心,多中心临床研究项目(DLY201613);上海交通大学医学院附属第九人民医院生物样本库项目(YBKA201902)。

摘　　要：颅外动静脉畸形(AVM)作为一种罕见且高风险的脉管畸形,尽管以血管内治疗和手术为主的治疗目前已经被接受,但在疾病的诊治方面仍然面临诸多挑战与困境。作者对颅外动静脉畸形的早期诊断与治疗、遗传学与病理机制,手术和介入技术的总结与创新,新型栓塞材料的研发与拓展等方面的最新进展进行了总结。另外,作者指出毛细血管畸形-AVM作为颅外AVM的一种特殊类型,在遗传学和对疾病认识上仍存许多未知有待探索。针对现状,作者进一步梳理了颅外AVM领域的关键性问题与前景,以协助从事颅外AVM诊疗的同行和专家一同促进学科发展。Extracranial arteriovenous malformation(AVM)is a rare but high-risk entity of all vascular malformations.Endovascular and surgical treatments become relatively well accepted.Challenges and dilemmas,however,still exist in the diagnosis and management of extracranial AVM.This up-to-date review focuses on the diagnosis and treatment of early-stage extracranial AVM,genetics and pathogenesis,the innovation and experience of surgical and endovascular techniques,and the development and expansion of novel embolization agents.In addition,we recognize that capillary malformation-arteriovenous malformation(CM-AVM),a special type of AVM,merits more investigation,in particular,in genetics and its relationship with AVM.This review proposes urgent issues and prospects for pioneers and experts to study extracranial AVM,so as to contribute to the advancement of this field.

关 键 词：颅外动静脉畸形 早期诊断 创新 遗传学 病理机制 

分 类 号：R74[医药卫生—神经病学与精神病学]