BRAP在新疆哈萨克族食管鳞状细胞癌及癌旁组织中的表达状况及临床意义  

Expression and Clinical Significance of BRAP in Xinjiang Kazakh’s ESCC and Corresponding Adjacent Normal Tissues

作　　者：吕作利 耿涛[2] 魏育涛[2] Lu Zuoli(Medical College of Shihezi University,Shihezi,Xinjiang 832000)

机构地区：[1]石河子大学医学院,新疆石河子832000 [2]石河子大学医学院第一附属医院心胸外二科,新疆石河子832000

出　　处：《黑龙江医药》2020年第3期495-498,共4页Heilongjiang Medicine journal

基　　金：国家自然科学基金项目(编号:81460059)。

摘　　要：目的:初步研究乳腺癌易感基因(BRCA1)相关蛋白(BRAP)在新疆哈萨克族食管鳞状细胞癌(Esophageal Squamous-Cell Carcinoma,ESCC)及癌旁组织中的表达状况并探讨其临床意义。方法:采用免疫组织化学法检测80例哈萨克族ESCC及癌旁组织中BRAP的表达状况。结果:(1)免疫组织化学结果显示BRAP在哈萨克族ESCC中阳性表达率为87.50%,在癌旁组织中阳性表达率为17.50%,差异具有统计学意义(P<0.001);(2)在哈萨克族ESCC中有淋巴结转移者BRAP的强阳性表达率为54.29%;无淋巴结转移者BRAP的强阳性表达率26.67%,差异具有统计学意义(P<0.05);(3)Kaplan-Meier生存分析结果显示在哈萨克族ESCC患者中BRAP过表达者预后较差。结论:BRAP在哈萨克族ESCC中高表达,且表达状况与肿瘤转移及患者生存期有关。Objective:A preliminary study on the expression of BRCA1 associated protein BRAP and its clinical significance in Kazakh’s Esophageal Squamous-Cell Carcinoma(ESCC)and corresponding adjacent normal tissues.Methods:The expression of BRAP in 80 cases of Kazakh’s ESCC and corresponding adjacent normal tissues were investigated by immunohistochemistry method.Results:(1)The results of Immunohistochemistry showed that the positive expression of BRAP was 87.50%in Kazakh’s ESCC tissues,17.50%in corresponding adjacent normal tissues,The rates were significantly different from each other(P<0.001);(2)In Kazakh’s ESCC tumors with positive lymph nodes,expression of ESCC was found in 54.29%,while only 26.67%in tumors with negative lymph nodes,which showed statistically difference(P<0.05);(3)The result of Kaplan-Meier analysis indicated that Kazakh’s ESCC patients with higher positive rate of BRAP had a poorer prognosis.Conclusion:The expression of BRAP in Kazakh’s ESCC tissues is high,the expression was related to tumor metastasis and patient survival.

关 键 词：新疆哈萨克族 BRAP ESCC 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]