细胞骨架相关蛋白2样蛋白在相关肿瘤发生发展中的作用  

Role of cytoskeleton-associated protein 2-like in tumor initiation and progression

作　　者：杨丽洁 杨铁成 王丹雯 王华桥 石丽稳 苏飞 谢伟[1] Yang Lijie;Yang Tiecheng;Wang Danwen;Wang Huaqiao;Shi Liwen;Su Fei;Xie Wei(Department of Gastrointestinal Surgery,Zhongnan Hospital,Clinical Medical Research Center of Peritoneal Cancer of Wuhan,Clinical Cancer Study Center of Hubei Provence,Key Laboratory of Tumor Biological Behavior of Hubei Provence,Wuhan 430071,China;Department of Oncology,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]武汉大学中南医院胃肠外科,武汉市腹膜癌临床医学研究中心,湖北省肿瘤医学临床研究中心,肿瘤生物学行为湖北省重点实验室,430071 [2]兰州大学第一医院肿瘤内科,730000

出　　处：《中华实验外科杂志》2020年第2期387-389,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(81770283);武汉市腹膜癌临床医学研究中心资助项目(2015060911020462);湖北省卫生与计划生育委员会科研基金资助项(WJ2015MA010、WJ2017M249);湖北省自然科学基金(2015CFA027);兰州大学第一医院院内项目(ldyyn2018-13)。

摘　　要：细胞骨架相关蛋白2样蛋白(CKAP2L),编码一个维持神经干/祖细胞(NSPCs)分化至关重要的蛋白,该蛋白位于NSPCs的径向纤维和有丝分裂纺锤体上,因此也被称为放射状纤维和有丝分裂纺锤体蛋白(Radmis)。研究证明CKAP2L在有丝分裂纺锤体形成和细胞周期中发挥重要作用。近年来,越来越多的证据表明CKAP2L与多种肿瘤的发生、发展密切相关。本文就CKAP2L在相关肿瘤发生发展中的作用做一综述。Cytoskeleton-associated protein 2-like(CKAP2L),which encodes a critical protein for maintaining the differentiation of neural stem/progenitor cells(NSPCs).It is also described as radial fiber and mitotic spindle(Radmis)on the basis of its localization to the radial fibers and the bipolar mitotic spindle of NSPCs.CKAP2L has been shown to take vital part in formation of mitotic spindles and cell cycle.In recent years,increasing evidence has shown that CKAP2L is closely related to the initiation and development of various tumors.This article reviews the role of CKAP2L in the development of related tumors.

关 键 词：细胞骨架相关蛋白2样蛋白 肿瘤 有丝分裂 细胞周期 

分 类 号：R730[医药卫生—肿瘤]