口腔微生物耐氟机制的研究进展  

Research progress in fluoride resistance mechanism of oral microorganism

作　　者：马锐 郭饶 王倩 刘建国 管晓燕 MA Rui;GUO Rao;WANG Qian;LIU Jian-Guo;GUAN Xiao-Yan(School of Stomatology,Zunyi Medical University,Zunyi,Guizhou 563006,China;Special Key Laboratory of Oral Disease Research,Higher Education Institution in Guizhou Province,Research Center;for Medicine and Biology,Zunyi Medical University,Zunyi,Guizhou 563006,China 3 Department of Orthodontics,Hospital of Stomatology,Zunyi Medical University,Zunyi,Guizhou 563099,China)

机构地区：[1]遵义医科大学口腔医学院,贵州遵义563006 [2]遵义医科大学医学与生物学研究中心贵州省普通高等学校口腔疾病研究特色重点实验室,贵州遵义563006 [3]遵义医科大学附属口腔医院正畸科,贵州遵义563099

出　　处：《微生物学通报》2020年第5期1607-1614,共8页Microbiology China

基　　金：口腔疾病研究国家重点实验室开放课题(SKLOD2017OF09);贵州省重点学科建设项目(黔学位合字ZDXK[2017]5);省市科技合作专项资金项目(省市科合(2014)41);遵义医学院优秀青年人才项目(17zy-002)。

摘　　要：氟化物一直被当作一种有效的抗龋药物广泛应用,但长期使用氟化物可能会导致耐氟菌株的出现,使其通过表型适应或基因型改变对氟产生抗性,降低氟化物防龋效果,且长期氟干扰可能引起口腔微生态失衡,从而诱发疾病。鉴于氟与口腔疾病防治的密切关系,以及口腔微生物稳态对于口腔乃至全身健康的重要作用,本文就口腔微生物耐氟机制的研究进展作一综述。Fluoride had been widely used as an effective anti-caries agent for decades.However,the long-term use of fluoride might lead to the emergence of fluoride-resistant strains.The fluoride-resistant ability of microorganism could be induced by the phenotypic adaptation or genotypic changes,subsequently,the anti-caries effect of fluoride might decrease.Besides,long-term fluoride interference might disturb the balance of oral micro-ecosystem,leading to associated oral diseases.In general,fluoride played an important role in the prevention and treatment of oral diseases,while oral microbial homeostasis was crucial for oral and systemic health.Therefore,in this paper we reviewed the research progress on the fluoride-resistant mechanism of oral microorganisms.

关 键 词：口腔微生物 耐氟性 氟化物核糖开关 基因突变 

分 类 号：R780.2[医药卫生—口腔医学]