Signaling networks in immunometabolism  

作　　者：Jordy Saravia Jana L.Raynor Nicole M.Chapman Seon Ah Lim Hongbo Chi 

机构地区：[1]Department of Immunology,St.Jude Children’s Research Hospital,Memphis,TN 38105,USA

出　　处：《Cell Research》2020年第4期328-342,共15页细胞研究（英文版）

基　　金：This work was supported by NIH AI105887,AI131703,AI140761,AI150241,AI150514 and CA221290(to H.C).

摘　　要：Adaptive immunity is essential for pathogen and tumor eradication,but may also trigger uncontrolled or pathological inflammation.T cell receptor,co-stimulatory and cytokine signals coordinately dictate specific signaling networks that trigger the activation and functional programming of T cells.In addition,cellular metabolism promotes T cell responses and is dynamically regulated through the interplay of serine/threonine kinases,immunological cues and nutrient signaling networks.In this review,we summarize the upstream regulators and signaling effectors of key serine/threonine kinase-mediated signaling networks,including PI3K-AGC kinases,mTOR and LKB1-AMPK pathways that regulate metabolism,especially in T cells.We also provide our perspectives about the pending questions and clinical applicability of immunometabolic signaling.Understanding the regulators and effectors of immunometabolic signaling networks may uncover therapeutic targets to modulate metabolic programming and T cell responses in human disease.

关 键 词：METABOLISM IMMUNITY IMMUNO 

分 类 号：R392[医药卫生—免疫学]