多胺对神经退行性疾病的改善作用  

The role of polyamines in neurodegenerative diseases

作　　者：王静[1,2] 刘森[1,2] WANG Jing;LIU Sen(Key Laboratory of Tumor Microenvironment and Immunotherapy,Medical School of China Three Gorges University,Yichang 443002,China;Key Laboratory of Fermentation Engineering(Ministry of Education)&National“111”Center for Cellular Regulation and Molecular Pharmaceutics,Hubei University of Technology,Wuhan 430068,China)

机构地区：[1]三峡大学医学院,肿瘤微环境与免疫治疗湖北省重点实验室,宜昌443002 [2]湖北工业大学教育部发酵工程重点实验室/细胞调控与分子药物111引智基地,武汉430068

出　　处：《生命的化学》2020年第4期513-519,共7页Chemistry of Life

基　　金：国家自然科学基金项目(31670768,31971150);湖北省杰出青年基金项目(2019CFA069);武汉市基础前沿研究项目(2018060401011319)。

摘　　要：多胺(polyamines)普遍存在于各种生物体中,参与多种生物学功能,包括细胞生长和增殖、蛋白质和核酸的合成、免疫细胞的分化、炎症反应的调节以及肠道功能的维持等。多胺主要包括腐胺(putrescine)、亚精胺(spermidine)、精胺(spermine)以及胍丁胺(agmatine)。随着衰老进程的发展,细胞内的多胺水平会逐渐随之降低。在衰老相关的神经退行性疾病的发生和发展过程中,多胺具有积极的作用。因此,本文就多胺对神经退行性疾病的改善作用作一综述,期望可以对未来神经退行性疾病的治疗和缓解提供参考。Polyamines are ubiquitous in all kinds of organisms and are involved in a variety of biological functions,including cell growth and proliferation,synthesis of proteins and nucleic acids,differentiation of immune cells,regulation of inflammatory responses and maintenance of intestinal function.Polyamines mainly include putrescine,spermidine,spermine and agmatine.As aging progresses,the cellular level of polyamines decreases gradually.Recent researches have shown that polyamines have positive effect on the occurrence and development of aging-related neurodegenerative diseases.This paper reviewed the positive role of polyamines in the treatment of neurodegenerative diseases,and hope to provide references for the treatment and remission of neurodegenerative diseases in the future.

关 键 词：亚精胺 精胺 胍丁胺 神经退行性疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]