MTHFR基因C677T多态性与亚洲人群偏头痛易感性的meta分析  

MTHFR gene C677T polymorphism and migraine susceptibility among Asian populations:a meta analysis

作　　者：王敏[1,2] 程小彬 李晶 李刚[1,2] WANG Min;CHENG Xiaobin;LI Jing;LI Gang(Department of Intensive Care Medicine,Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan,Hubei 430061 China;Hubei Province Academy of Traditional Chinese Medicine,Wuhan,Hubei 430074 China)

机构地区：[1]湖北省中医院重症医学科,武汉430061 [2]湖北省中医药研究院,武汉430074

出　　处：《重庆医学》2020年第12期1998-2002,2012,共6页Chongqing medicine

摘　　要：目的探讨亚甲基四氢叶酸还原酶基因C677T多态性与亚洲人群偏头痛(包括先兆偏头痛和无先兆偏头痛)易感性之间的关系。方法全面检索PubMed、Embase、中国知网(CNKI)、万方、维普等数据库筛选关于C677T多态性与偏头痛易感性相关的病例-对照研究。采用Stata14.0软件进行meta分析,并进行偏头痛类型亚组分析。结果最终纳入文献11篇,包含试验组1341例和对照组1563例。meta分析结果显示,C677T各基因型与亚洲人群偏头痛易感性之间存在明显相关性(T vs.C,OR=1.67,95%CI:1.19~2.35,P<0.01;TT vs.CC,OR=2.31,95%CI:1.33~4.02,P<0.01;CT vs.CC,OR=1.56,95%CI:1.06~2.31,P=0.02;CT+TT vs.CC,OR=1.77,95%CI:1.16~2.72,P<0.01;TT vs.CT+CC,OR=1.92,95%CI:1.16~3.19,P<0.01),各基因型与先兆偏头痛易感性有关,与无先兆偏头痛的发病风险不存在关联。结论在亚洲人群中,MFTHR基因C667T多态性可能是偏头痛总体人群及先兆偏头痛人群发病的风险因素。Objective To investigate the relationship between methylenetetrahy-drofolate reductase(MTHFR)gene C677T polymorphism and migraine(including migraine with aura and migraine without aura)susceptibility among Asian populations.Methods The case control studies on the correlation between C677T polymorphism and migraine susceptibility were screened from the databases of PubMed,Embase,CNKI,Wanfang and VIP.The meta analysis was performed by using the Stata 12.0 software,moreover the subtype analysis of migraine was performed.Results A total of 11 papers were included,involving 1341 cases in the experiment group and 1563 cases in the control group.The meta analysis results indicated that there was obvious correlation between C677T getotypes and migraine susceptibility in Asia populations(T vs.C,OR=1.67,95%CI:1.19-2.35,P<0.01;TT vs.CC,OR=2.31,95%CI:1.33-4.02,P<0.01;CT vs.CC,OR=1.56,95%CI:1.06-2.31,P=0.02;CT+TT vs.CC,OR=1.77,95%CI:1.16-2.72,P<0.01;TT vs.CT+CC,OR=1.92,95%CI:1.16-3.19,P<0.01),the various genotypes were related with the susceptibility of migrane with aura and had no relation with the onset risk of migrane without aura.Conclusion MFTHR gene C677T polymorphism may be the risk factors of onset in the total populations of migraine and the populations of migraine with aura.

关 键 词：偏头痛 亚甲基四氢叶酸还原酶基因 C677T 多态性 META分析 

分 类 号：R747.2[医药卫生—神经病学与精神病学]