肺腺癌EGFR突变状态与临床特征相关分析  

Correlation analysis of clinical features with EGFR mutant of lung adenocarcinoma

作　　者：张文霞[1] 张一卓[1] 王丽娟 韦红[1] 朱启峰[1] ZHANG Wenxia;ZHANG Yizhuo;WANG Lijuan;WEI Hong;ZHU Qifeng(Heze Municiple Hospital,Heze 274000,Shandong)

机构地区：[1]菏泽市立医院,山东菏泽274000

出　　处：《菏泽医学专科学校学报》2020年第2期4-6,41,共4页Journal of Heze Medical College

摘　　要：目的探讨表皮生长因子受体(EGFR)突变型肺腺癌的临床特征及影像学特点。方法回顾性分析我院资料完整进行EGFR检测的肺腺癌患者90例,分析其性别、年龄、发生部位、吸烟、脑转移、骨转移、CEA水平等与突变状态的关系,影像学特征包括肿块大小、有无毛玻璃(GGO)、有无毛刺与突变状态的关系。结果90例患者中EGFR突变者54例,突变率60%,经卡方检验性别、吸烟、脑转移、CEA水平、肿瘤直径、GGO成分、毛刺症有显著差异(P<0.05)。多因素分析只有肿瘤直径、有无GGO成分与突变状态显著相关,直径小、含有GGO成分是EGFR突变的独立预测因子。结论肺腺癌EGFR突变状态与临床特征及影像学特点存在一定相关性,需要通过进一步临床试验验证。Objective To investigate the clinical and imaging characteristics of EGFR mutant of lung adenocarci⁃noma.Methods The study retrospectively analyzed 90 cases of patients with lung adenocarcinoma with detection of EGFR.The relation of gender,age,location,smoking,brain metastases and bone metastases and CEA levels with the mu⁃tation was analyzed and the relation of tumor size,presence of frosted glass(GGO),presence of burrswith mutation sta⁃tus was also analyzed.Results Among the 90 patients,54 cases had EGFR mutation,whose mutation rate was 60%.There were significant differences in gender,smoking,brain metastasis,CEA level,tumor diameter,GGO components and burr syndrome by chi-square test(P<0.05).In multivariate analysis,only tumor diameter and the presence or absence of GGO component were significantly correlated with mutation status.Small diameter and GGO component were inde⁃pendent predictors of EGFR mutation.Conclusion EGFR mutation in lung adenocarcinoma has a certain correlation with clinical characteristics and imaging characteristics,which needs to be verified by further clinical trials.

关 键 词：肺腺癌 表皮生长因子受体 基因突变 

分 类 号：R734.2[医药卫生—肿瘤]