膳食N-羟乙酰神经氨酸摄入水平与机体慢性炎症状态的相关性研究  

Study on the correlation between dietary N-glycolylneuraminic acid intake and chronic inflammation state of body

作　　者：庄滢滢 郑晗盈 兰慧 李红卫[1] Zhuang Yingying;Zheng Hanying;Lan Hui;Li Hongwei(School of Public Health,Xiamen University,Xiamen 361101,China)

机构地区：[1]厦门大学公共卫生学院,361101

出　　处：《中华预防医学杂志》2020年第6期668-672,共5页Chinese Journal of Preventive Medicine

基　　金：达能膳食营养研究与宣教基金项目(DIC2012-12)。

摘　　要：目的探讨膳食N-羟乙酰神经氨酸(Neu5Gc)摄入水平与机体慢性炎症状态的关系。方法所有食物样品均于2019年9月购自厦门某超市,包括谷物、肉类、家禽、海鲜、鸡蛋、豆类、乳制品、蔬菜和水果等,共计102种306份,采用液相色谱-质谱联用法测定食物Neu5Gc含量。采用简单随机抽样抽取厦门大学健康入学新生500名,采用食物频率调查表调查研究对象过去1年内食物摄入情况,采用连续3 d 24 h回顾法校正食用量,计算对象的Neu5Gc摄入量。检测血清抗-Neu5Gc抗体、C反应蛋白(CRP)和白细胞介素-6(IL-6)水平。采用Spearman相关分析探索Neu5Gc摄入量与抗-Neu5Gc抗体以及CRP和IL-6等指标的相关性。结果Neu5Gc主要存在于红肉和液态乳制品,在牛、羊和猪肉中的含量分别为(30.32±2.84)、(20.39±4.73)和(5.58±1.04)mg/kg,在液态牛奶和酸奶中的含量分别为(10.87±1.54)和(6.91±0.24)mg/L。Neu5Gc摄入量的M(P25,P75)为4.62(2.20,8.60)mg/d,其中男生为6.60(2.83,10.20)mg/d,高于女生[3.84(1.84,6.35)mg/d](P<0.001)。血清抗-Neu5Gc、CRP和IL-6水平的M(P25,P75)分别为3.07(2.17,4.14)μg/ml,0.37(0.22,0.87)mg/ml和61.82(12.23,315.30)pg/ml。Neu5Gc摄入水平与血清抗-Neu5Gc抗体、CRP和IL-6水平均呈正相关,rs值分别为0.222、0.102和0.126,P值均<0.05。结论膳食Neu5Gc摄入主要来自红肉和液态乳制品,其摄入水平与机体慢性炎症状态呈正相关。Objective To explore the correlation between dietary N-glycolylneuraminic acid(Neu5Gc)intake and chronic inflammation state of body.Methods A total of 306 samples of 102 types of food were purchased from a supermarket in Xiamen in September 2019,including grains,meat,poultry,seafood,eggs,beans,dairy products,vegetables and fruits.The content of Neu5Gc in food was determined by liquid chromatography-mass spectrometry.A total of 500 healthy freshmen from Xiamen University were selected by using a simple random sampling method.The food frequency questionnaire was used to investigate the food intake in the past year.The food intake was corrected by 3 consecutive 24-hour recalls,and the amount of Neu5Gc intake was calculated.The concentration of anti-Neu5Gc antibody,C-reactive protein(CRP)and interleukin-6(IL-6)in serum was detected.Spearman correlation analysis was used to explore the correlation between Neu5Gc intake and anti-Neu5Gc antibody,CRP and IL-6 levels.Results Neu5Gc was mainly found in red meat and liquid dairy products.The contents of Neu5Gc in beef,lamb and pork were(30.32±2.84),(20.39±4.73)and(5.58±1.04)mg/kg,respectively,and in liquid milk and yogurt were(10.87±1.54)and(6.91±0.24)mg/L,respectively.The M(P25,P75)intake of Neu5Gc for all participants was 4.62(2.20,8.60)mg/d.The M(P25,P75)intake of Neu5Gc for males about 6.60(2.83,10.20)was higher than that for females about[3.84(1.84,6.35)mg/d](P<0.001).The M(P25,P75)of serum anti-Neu5Gc,CRP and IL-6 levels were 3.07(2.17,4.14)μg/ml,0.37(0.22,0.87)mg/ml and 61.82(12.23,315.30)pg/ml,respectively.Spearman correlation analysis showed that the intake level of Neu5Gc was positively correlated with serum anti-Neu5Gc antibody,CRP and IL-6 levels,with rs values about 0.222,0.102 and 0.126,respectively(all P values<0.05).Conclusion Dietary Neu5Gc intake is mainly from red meat and liquid dairy products,and its intake level is positively correlated with chronic inflammatory state of body.

关 键 词：膳食 唾液酸类 炎症 横断面研究 

分 类 号：R151[医药卫生—营养与食品卫生学]