颞叶癫痫认知障碍的神经网络机制  

Neural network mechanism of cognitive impairment in temporal lobe epilepsy

作　　者：陈翠 陈湛愔 CHEN Cui;CHEN Zhan-yin(Guangdong Medical University,Zhanjiang 524023,China;Zhanjiang Central Hospital Affiliafed Hospital of Guangdong Medical University,Zhanjiang 524037,China)

机构地区：[1]广东医科大学,广东湛江524023 [2]广东医科大学附属湛江中心人民医院,广东湛江524037

出　　处：《广东医科大学学报》2020年第3期259-262,共4页Journal of Guangdong Medical University

基　　金：广东省社会发展基金(NO.2011B031800397);广东省自然科学基金项目(NO.2013B021800109)。

摘　　要：大脑的认知编码系统形成自身独特的认知网络,该过程涉及到复杂的颞叶认知网络系统.颞叶癫痫反复发作可破坏兴奋-抑制性突触传导,损伤认知网络结构连通;后期泛化至整个大脑认知网络系统引起结构性破坏,导致不可逆认知损害,尤其是空间记忆障碍,但其确切机制不明.该文综述了颞叶癫痫网络与认知衰退之间的潜在机制,认为兴奋-抑制平衡失调起关键作用.The cerebral cognitive coding system forms its own unique cognitive network,which involves a complex cognitive network system in temporal lobes.Recurrent seizures of temporal lobe epilepsy can destroy excitatory-suppressive synaptic transmission and impair the cognitive network connection;and terminal generalization of entire brain cognitive network system causes structural destruction and irreversible cognitive damage(especially spatial allomnesia).However,the precise mechanism is unclear.This paper reviews the potential mechanism between temporal lobe epilepsy network and cognitive deterioration,and suggests the pivotal role of excitement-inhibition imbalance in temporal lobe epilepsy.

关 键 词：颞叶癫痫 认知障碍 神经网络 兴奋-抑制平衡 

分 类 号：R742.1[医药卫生—神经病学与精神病学]