Polysubstituted Phenyl Glucosides Produced by the Fungus Metarrhizium anisopliae  

作　　者：Wen-jing WANG Chong DAI Jian-ping WANG Hu-cheng ZHU Chun-mci CHEN Yong-hui ZHANG 

机构地区：[1]Hubei Key Laboratory of Naural Medicinal Chemistry and Resource Evaluation,Tongji Medical College,Huazhong Universiry of Science and Technology,Wuhan 430030,China

出　　处：《Current Medical Science》2020年第2期232-238,共7页当代医学科学（英文）

基　　金：This work was financially supported by the Program for Changjiang Scholars of Ministry of Education of the People's Republic of China(No.T2016088);the National Natural Science Foundation for Distinguished Young Scholars(No.81725021);the National Natural Science Foundation of China(No.31900288);the Program from the(hina Postdoctoral Science Foundation(No.2019M652660);the Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College(HUST,China).

摘　　要：MetarhizosidesA-G(1-7),seven new polysubstituted phenyl glucosides,were isolated from the extracts of solid rice medium of a marine-derived fungus Metarrhizium anisopliae.Compounds 1-7 all contain a polysubstituted phenyl group and the sugar unit is identified as 4'-O-methyl-β-D-glucopyranose.Their structures were elucidated by NMR spectroscopy and chemical method.These compounds were evaluated for anti-inflammatory activity by using LPS-stimulated murine macrophage RAW 264.7 cells and the cytotoxicities against four human cancer cell lines.

关 键 词：marine-derived fungus GLUCOSIDES Metarrhizium anisopliae ANTI-INFLAMMATION cytotoxicities 

分 类 号：O62[理学—有机化学]