Non-covalent glycosylated gold nanoparticles/peptides nanovaccine as potential cancer vaccines  

作　　者：Liming Zeng Zonglang Liao Wenwei Li Qijuan Yuan Peng Wu Zhipeng Gu Zhongqiu Liu Guochao Liao 

机构地区：[1]Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China,International Institute for Translational Chinese Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China [2]School of Biomedical Engineering,Sun Yat-sen University,Guangzhou 510006.China

出　　处：《Chinese Chemical Letters》2020年第5期1162-1164,共3页中国化学快报（英文版）

基　　金：the Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine(No.20188030322011);the National Natural Science Foundation of China(No.81773580)。

摘　　要：Herein,we firstly developed a non-covalent glycosylated gold nanoparticles/peptides nanovaccine which is assembled byβ-cyclodextrin(β-CD)based host-guest recognitions.This nanovaccine can generate significant titers of antibodies and improve the therapeutic effect against melanoma,suggesting the immunogenicity of peptide antigens can be improved by loading with this carrier.The novel vaccine carrier provides a platform for the transport of various antigens especially T cell-independent antigens.

关 键 词：NON-COVALENT GLYCOSYLATION Nanoparticles/peptides nanovaccine β-Cyclodextrin Host-guest recognitions Cancer vaccines 

分 类 号：TQ464[化学工程—制药化工]