NON-COVALENT

作品数:42被引量:79H指数:4
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相关领域:理学更多>>
相关作者:朱文杰薛喜文赵永娟张亮仁刘振明更多>>
相关机构:北京大学上海大学兰州交通大学更多>>
相关期刊:《Chinese Journal of Structural Chemistry》《Journal of Energy Chemistry》《Bioactive Materials》《Journal of Chinese Pharmaceutical Sciences》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划以色列科学基金中国博士后科学基金更多>>
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Cucurbit[8]uril-based non-covalent heterodimer realized NIR cell imaging through topological transformation from nanowire to nanorod
《Chinese Chemical Letters》2024年第10期262-268,共7页Jianqiu Li Yi Zhang Songen Liu Jie Niu Rong Zhang Yong Chen Yu Liu 
National Natural Science Foundation of China(Nos.22131008 and 21971127);the Fundamental Research Funds for the Central Universities;the Haihe Laboratory of Sustainable Chemical Transformations for financial support。
In recent years,multicolor cascade supramolecular assemblies with controllable topological morphology have become a research hotspot due to their wide application in light-emitting materials,cell imaging and other fie...
关键词:Multivalent assemblies CUCURBITURIL Morphological transformation Targeted imaging 
Microstructure Regulation and Combustion Performance Optimization of PVDF/Al Composite Powder by Non-covalent Functionalized Graphenes
《Journal of Wuhan University of Technology(Materials Science)》2024年第4期904-911,共8页易卓然 DENG Haoyuan QIN Mei 孙一 LUO Guoqiang 
Funded by the National Natural Science Foundation of China(No.52104363)。
Graphene prepared by non-covalent modification of sulfonated poly(ether-ether-ketone)(SPG)was combined with polyvinylidene fluoride(PVDF)/Al to improve the PVDF/Al thermal conductivity while reducing the effect of the...
关键词:energetic materials PVDF/Al composites graphene modification energy release combustion 
Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
《Acta Pharmaceutica Sinica B》2024年第7期3286-3290,共5页Miao Zheng Bo Feng Yumin Zhang Xin Liu NaZhao Hui Liu Zichao Xu Xinheng He Zhiyan Qu ShizhaoChen Zhidong Jiang Xi Cheng Hong Liu Yi Zang Linxiang Zhao Jie Zheng Leike Zhang Jia Li Yu Zhou 
National Natural Science Foundation of China(82151219,82130105);the Strategic Priority Research Program of Chinese Academy of Sciences(SIMM010109,SIMM010111);Shanghai Institute of Materia Medica of Chinese Academy of Sciences(SIMM0120231003)for the financial support.
To the Editor:The papain-like protease(PL^(pro)),as one of the most important proteases of SARS-CoV-2,has emerged as a highly promising target protein,its inhibitor probably holds dual potentials,namely blocking the c...
关键词:Non-covalent PL^(pro)inhibitors Antiviral activity Structural-based drug design Imidazo[4 5-b]pyridine scaffold 
Merging non-covalent and covalent crosslinking:En route to single chain nanoparticles
《Chinese Chemical Letters》2024年第6期307-311,共5页Yifei Zhang Yuncong Xue Laiwei Gao Rui Liao Feng Wang Fei Wang 
supported by the National Natural Science Foundation of China(Nos.22371272 and 22301295);the Fundamental Research Funds for the Central Universities(Nos.YD2060002036 and WK5290000004);International Partnership Program of the Chinese Academy of Sciences(No.123GJHZ2022064MI);the Collaborative Innovation Program of Hefei Science Center,CAS(No.2022HSC-CIP014)。
Single-chain nanoparticles represent an emerging class of nanomaterials designed to mimic protein's folding paradigm.Intrachain covalent crosslinking toward the formation of single-chain nanoparticles encounters compl...
关键词:Single chain nanoparticles Intrachain folding Supramolecular confinement Cyanostilbenes [2+2]photocycloaddition 
Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors被引量:2
《Acta Pharmaceutica Sinica B》2024年第1期87-109,共23页Letian Song Shenghua Gao Bing Ye Mianling Yang Yusen Cheng Dongwei Kang Fan Yi Jin-Peng Sun Luis Menéndez-Arias Johan Neyts Xinyong Liu Peng Zhan 
We gratefully acknowledge financial support from Major Basic Research Project of Shandong Provincial Natural Science Foundation(ZR2021ZD17,China);Science Foundation for Outstanding Young Scholars of Shandong Province(ZR2020JQ31,China);Foreign Cultural and Educational Experts Project(GXL20200015001,China);Guangdong Basic and Applied Basic Research Foundation(2021A1515110740,China);China Postdoctoral Science Foundation(2021M702003);This work was supported in part by the Ministry of Science and Innovation of Spain through grant PID2019-104176RBI00/AEI/10.13039/501100011033 awarded to Luis Menéndez-Arias;An institutional grant of the Fundación Ramón Areces(Madrid,Spain)to the CBMSO is also acknowledged.Luis Menéndez-Arias is member of the Global Virus Network.
The main protease(M^(pro))of SARS-CoV-2 is an attractive target in anti-COVID-19 therapy for its high conservation and major role in the virus life cycle.The covalent M^(pro)inhibitor nirmatrelvir(in combination with ...
关键词:COVID-19 SARS-CoV-2 Main protease Non-covalent inhibitors Medicinal chemistry strategies 
Recent advances in two-step energy transfer light-harvesting systems driven by non-covalent self-assembly
《Chinese Chemical Letters》2024年第1期31-39,共9页Zhiying Wu Hongwei Qian Xiuxiu Li Tangxin Xiao Leyong Wang 
the National Natural Science Foundation of China(No.21702020)is gratefully acknowledged。
Sequential energy transfer is ubiquitous in natural light-harvesting systems(LHSs),which greatly promotes the exploitation of light energy.The LHSs in nature are sophisticated supramolecular assemblies of chlorophyll ...
关键词:Light-harvesting system Supramolecular self-assembly Sequential energy transfer Tunable fluorescence FRET 
Correction: Discovery of novel non-peptidic and non-covalent small-molecule 3CL^(pro) inhibitors as potential candidate for COVID-19 treatment
《Signal Transduction and Targeted Therapy》2023年第11期5563-5564,共2页Zhidong Jiang Bo Feng Yumin Zhang Tianqing Nie Hong Liu Jia Li Haixia Su Leike Zhang Yi Zang Yu Zhou 
In our recent review of the article[1],the author noticed that the dots(red squares)in Fig 1m were accidentally removed from its original location during figure formatting,and the related data analysis is correct.Furt...
关键词:checked removed TREATMENT 
Production and utilization of non-covalent dairy-based proteins complexed with date palm leave polyphenols for improving curcumin stability
《Food Bioscience》2023年第3期1909-1919,共11页Waqas N.Baba Raghad Abdelrahman Sajid Maqsood 
UAE university for funding this study through Zayed Center for Health Sciences grant(12R116).
This study provides insights into the non-covalent complexation of greent solvent extracted date leaf polyphenolic extracts(DLPE)with bovine and camel dairy proteins and their utilization for enhancing the photo and t...
关键词:“Camel”and“bovine” “Casein”and“whey” CURCUMIN NANOEMULSIONS STABILITY Bioaccesibility 
Discovery of novel non-peptidic and non-covalent small-molecule 3CL^(pro)inhibitors as potential candidate for COVID-19 treatment
《Signal Transduction and Targeted Therapy》2023年第6期2467-2470,共4页Zhidong Jiang Bo Feng Yumin Zhang Tianqing Nie Hong Liu Jia Li Haixia Su Leike Zhang Yi Zang Yu Zhou 
supported by the National Natural Science Foundation of China(82151219,82130105);the Strategic Priority Research Program of the Chinese Academy of Sciences(SIMM010109,SIMM010111);the Qiusuo Outstanding Youth Project of Lingang Laboratory(LG-QS-202205-02).
Dear Editor,The global coronavirus disease 2019(COVID-19)pandemic,which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has brought a profound impact on humanity.SARS-CoV-2 enters host cells th...
关键词:ACE2 acute RESPIRATORY 
The interaction mechanism and the functionality of yeast protein with hydrophilic and hydrophobic bioactive molecules被引量:2
《Food Bioscience》2023年第2期990-999,共10页Haili Sun Yifei Sun Xin Tang Yuanmeng Cui Demei Meng Yuyu Zhang Ku Li Hui Guo Hai Chen Rui Yang 
This work was supported by the Natural Science Foundation of Tianjin City,China(No.20JCYBJC00020);the National Natural Science Foundation of China(No.31972067);the Beijing Outstanding Young Scientist Program(BJJWZYJH01201910011025);the fund from Key Technology of Biological Manufacturing of Yeast Products with Salt reduction and Flavor Enhancement(No.2020ZYYD028);the Project Program of Key Laboratory of Tianjin Key Laboratory of Food Quality and Health,China(No.TJS202203).
Yeast protein is a kind of yeast-source high-quality complete protein.The coexistence of bioactive molecules with yeast protein may influence its physicochemical property.This study discussed the interaction mechanism...
关键词:Yeast protein Bioactive ligands Non-covalent binding Stability EMULSIFICATION 
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