Hyperinoids A and B,two polycyclic meroterpenoids from Hypericum patulum  

作　　者：Xinyu Jia Yongmei Wu Chun Lei Yanyan Yu Jianqi Li Jingya Li Aijun Hou 

机构地区：[1]School of Pharmacy,State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 201203,China [2]National Center for Drug Screening,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [3]Shanghai Institute of Pharmaceutical Industry,Shanghai 201203,China

出　　处：《Chinese Chemical Letters》2020年第5期1263-1266,共4页中国化学快报（英文版）

基　　金：financially supported by Fudan-SIMM Joint Research Fund(No.FU-SIMM20181011)。

摘　　要：Hyperinoids A(1)and B(2),two prenylated acylphloroglucinol related meroterpenoids,were isolated from Hypericum patulum.Compound 1 incorporates an unprecedented 11,12-dioxatetracyclo[5.4.3.01,7.04,14]tetradecane system,while 2 possesses a unique 10,11-dioxatetracyclo[5.3.3.01,7.04,13]tridecane syste m.Their structures were established by spectro scopic analysis and X-ray crystallographic data.Compounds 1 and 2 were identified as potent NF-κB inhibitors and suppressed the LPS-induced inflammatory responses in RAW 246.7 macrophages and primary mouse BMDM cells.

关 键 词：MEROTERPENOIDS Hyperinoids A and B ANTI-INFLAMMATION Hypericum patulum GUTTIFERAE 

分 类 号：O629[理学—有机化学]