HP感染后Men1基因对非酒精性脂肪肝病及炎症反应的调控机制  

Effect of Men1 Gene on Nonalcoholic Fatty Liver Disease and Inflammatory Response after Helicobacter pylori Infection

作　　者：方德周 方彦旭 贾星星 Fang Dezhou;Fang Yanxu;Jia Xingxing(General Hospital of Guizhou Panjiang Investment Holding Group Co.,Ltd.,Liupanshui,553536)

机构地区：[1]贵州省盘江投资控股(集团)有限公司总医院,六盘水553536

出　　处：《基因组学与应用生物学》2020年第4期1824-1829,共6页Genomics and Applied Biology

摘　　要：为了研究HP感染后Men1基因对NAFLD小鼠的调控机理,本研究检测了Men1基因和蛋白在NAFLD+HP和NAFLD组小鼠中的表达,同时检测了炎症因子IL-6和IL-18基因以及含量的变化。结果表明,HP感染后NAFLD小鼠中Men1基因和蛋白的表达均显著下调,但是IL-6和IL-18基因和含量均显著上调和增加。结合前人的研究报道结果,本研究推断Men1基因可能会与小鼠体内的其它因子协同来影响IL-6和IL-18等炎症因子的表达,而Men1基因下调阻断了这种协同作用,从而使IL-6和IL-18等炎症因子表达上调,促进小鼠肝脏的损伤程度。因此本实验的结果表明,Men1基因可能会是治疗HP感染后NAFLD的一个有效的靶点,改变其表达量就能调节HP感染的非酒精性脂肪肝病的严重程度。In order to study the regulation mechanism of Men1 gene in NAFLD mice after HP infection,this study detected the expression of Men1 gene and protein in NAFLD+HP and NAFLD mice,as well as the changes of inflammatory cytokines IL-6 and L-18 genes and their content.The results showed that the expression of Men1 gene and protein in NAFLD mice were significantly down-regulated after HP infection,but the IL-6 and L-18 genes and content were significantly up-regulated and increased.Combined with previous studies,we hypothesized that the Men1 gene may interact with other factors in mice to affect the expression of inflammatory cytokines such as IL-6 and IL-18.Down-regulation of the Men1 gene blocks this synergy,thereby the expression of inflammatory factors such as IL-6 and IL-18 are up-regulated,which promotes the degree of liver damage in mice.Therefore,the results of this experiment indicate that the Men1 gene may be an effective target for the treatment of NAFLD after HP infection,and changing the expression level can regulate the severity of HP-infected non-alcoholic fatty liver disease.

关 键 词：NAFLD 非酒精性脂肪肝 HP 幽门螺杆菌(Helicobacter pylori) MEN1 

分 类 号：R575.5[医药卫生—消化系统]