This work was supported by the grants from the National Natural Science Foundation of China(Nos.82141129,82173281,82173282,82172577,82172948,81972725,81972250,U21A20374,and 81871950);Science and Technology Commission of Shanghai Municipality(No.20ZR1471100);Shanghai Municipal Science and Technology Major Project(No.21JC1401500);Scientific Innovation Project of Shanghai Education Committee(No.2019-01-07-00-07-E00057);Clinical Research Plan of Shanghai Hospital Development Center(No.SHDC2020CR1006A);Xuhui District Artificial Intelligence Medical Hospital Cooperation Project(No.2021-011),Commission of Health and Family Planning(No.2018YQ06);Shanghai Municipal Science and Technology Commission(No.19QA1402100)。
Pancreatic neuroendocrine tumor(pNET)is the second most common malignant tumors of the pancreas.Multiple endocrine neoplasia 1(MEN1)is the most frequently mutated gene in pNETs and MEN1-encoded protein,menin,is a scaf...
The ultimate goal of cancer genetics is to exploit molecular changes in a cancer to design tumor specific therapies.Ma et al.in their recent paper in Cell Research used an elegant strategy,a CRISPR-Cas9 synthetic leth...
supported by the National Key R&D Program of China(2021YFC2501004,2021YFC2500900);the National Natural Science Foundation Fund(81772490,82172988,81972311,82141127);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS)(2021-1-I2M-018,2021-I2M-1-067,2021-1-I2M-012 and 2021-I2M-1-066);the Non-profit Central Research Institution Fund of Chinese Academy of Medical Sciences(2019PT310026);Sanming Project of Medicine in Shenzhen(SZSM202011010).
Dear Editor,Multiple endocrine neoplasia 1(MEN1)syndrome,a tumor predisposition disease caused by MEN1 germline mutation,is characterized by combined occurrence of neuroendocrine tumors(NETs)in multiple organsJ Pancre...