Synthetic lethal screening identifies DHODH as a target for MEN1-mutated tumor cells  

作　　者：Yarui Ma Qing Zhu Xiaobing Wang Mei Liu Qichen Chen Liming Jiang Yihebali Chi Yi-Xin Zeng Hong Zhao Yuchen Jiao 

机构地区：[1]State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China [2]Department of Medical Oncology,Beijing Hospital,National Center of Gerontology and Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing,China [3]Department of Clinical Laboratory Diagnostics,Beijing Friendship Hospital,Capital Medical University,Beijing,China [4]Key Laboratory of Gene Editing Screening and R&D of Digestive System Tumor Drugs,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China [5]Department of Hepatobiliary Surgery,State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China [6]Department of Diagnostic Imaging,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China [7]Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China [8]State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Sun Yat-sen University Cancer Center,Guangzhou,China [9]Department of Clinical Laboratory,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China

出　　处：《Cell Research》2022年第6期596-599,共4页细胞研究（英文版）

基　　金：supported by the National Key R&D Program of China(2021YFC2501004,2021YFC2500900);the National Natural Science Foundation Fund(81772490,82172988,81972311,82141127);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS)(2021-1-I2M-018,2021-I2M-1-067,2021-1-I2M-012 and 2021-I2M-1-066);the Non-profit Central Research Institution Fund of Chinese Academy of Medical Sciences(2019PT310026);Sanming Project of Medicine in Shenzhen(SZSM202011010).

摘　　要：Dear Editor,Multiple endocrine neoplasia 1(MEN1)syndrome,a tumor predisposition disease caused by MEN1 germline mutation,is characterized by combined occurrence of neuroendocrine tumors(NETs)in multiple organsJ Pancreatic neuroendocrine tumors(PanNETs)are the major cause of the increased mortality in MEN1 patie nts due to the most maligna nt potential.

关 键 词：MEN1 ORGANS MORTALITY 

分 类 号：R730[医药卫生—肿瘤]