Therapeutic effect of heat-sensitive moxibustion plus medications for senile osteoporosis and its effect on serum BMP-2 and OPG levels  

热敏灸加药物治疗老年性骨质疏松症疗效及对血清BMP-2和OPG水平的影响

作　　者：Li Juan Liu Gui-ping 李娟;刘桂平(Lin'an District People's Hospital of Hangzhou,Zhejiang Province,Hangzhou 311300,China;Chun'an Orthopedic Hospital of Hangzhou,Zhejiang Province,Hangzhou 311700,China)

机构地区：[1]Lin'an District People's Hospital of Hangzhou,Zhejiang Province,Hangzhou 311300,China [2]Chun'an Orthopedic Hospital of Hangzhou,Zhejiang Province,Hangzhou 311700,China

出　　处：《Journal of Acupuncture and Tuina Science》2020年第3期213-218,共6页针灸推拿医学（英文版）

摘　　要：Objective:To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis(SOP),and to explore the related mechanisms.Methods:A total of 70 elderly participants with osteoporosis were randomly divided into an observation group and control group,with 35 cases in each group.The control group was treated with conventional drugs,and the observation group was treated with heat-sensitive moxibustion on the basis of the conventional drugs.Both groups were treated for 3 months.Before and after treatment,assessed the visual analog scale(VAS)and Oswestry disability index(ODI)scores,determined the bone mineral density of the participants'lumbar spine(L2-L4)and left femoral neck,and detected the participants'serum bone morphogenetic protein-2(BMP-2)and osteoprotegerin(OPG)levels.Results:After treatment,the VAS scores of both groups were lower than before treatment(both P<0.05),and the VAS score of the observation group was significantly lower than that of the control group(P<0.05).After treatment,the bone mineral density values of the lumbar spine and left femoral neck in both groups were significantly higher than before treatment(both P<0.05),and the bone mineral density values of the observation group were higher than those of the control group(P<0.05).After treatment,the ODI scores of the two groups were lower than those before treatment(both P<0.05),and the ODI score of the observation group was lower than that of the control group(P<0.05).After treatment,the serum BMP-2 and OPG levels in the observation group were significantly higher than those in the control group(both P<0.05).Conclusion:Heat-sensitive moxibustion plus medications for SOP can significantly relieve patients'pain,improve dysfunction,and increase bone density,which may be related to the improvement of the serum BMP-2 and OPG levels.目的:观察热敏灸加药物治疗老年性骨质疏松症(SOP)的临床疗效,并探讨相关作用机制.方法:将70例老年性骨质疏松症患者随机分为观察组和对照组,每组35例.对照组予常规药物治疗,观察组在常规药物基础上加热敏灸治疗,两组均治疗3个月.治疗前后进行视觉模拟量表(VAS)和Oswestry功能障碍指数(ODI)评分,测定患者腰椎(L2-L4)及左股骨颈的骨密度值,并检测患者血清骨形态发生蛋白-2(BMP-2)和骨保护蛋白(OPG)水平.结果:治疗后,两组VAS评分均较治疗前降低(均P<0.05),观察组VAS评分明显低于对照组(P<0.05).治疗后,两组腰椎及左股骨颈的骨密度值均较治疗前明显升高(均P<0.05),且观察组的骨密度值高于对照组(P<0.05).治疗后,两组患者ODI评分均较治疗前降低(均P<0.05),观察组ODI评分低于对照组(P<0.05).治疗后,观察组血清BMP-2和OPG水平明显高于对照组(均P<0.05).结论:热敏灸加药物治疗SOP可明显缓解患者疼痛症状,改善功能障碍,增加骨密度,可能与其改善患者血清BMP-2和OPG水平相关.

关 键 词：Moxibustion Therapy Moxa Stick Moxibustion Heat-sensitive Moxibustion OSTEOPOROSIS Aged Bone Density Bone Morphogenetic Protein-2 OSTEOPROTEGERIN 

分 类 号：R246.2[医药卫生—针灸推拿学]