Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes  

作　　者：Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang 

机构地区：[1]State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China [2]Department of Thoracic Surgery,Anyang Tumor Hospital,Anyang 455000,China [3]Department of Histology and Embryology,School of Basic Medical Sciences,Xinxiang Medical University,Xinxiang 453000,China [4]Department of Thoracic Surgery,Linzhou People's Hospital,Linzhou 456550,China [5]Department of Pathology and Pathophysiology,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450000,China [6]Department of Pathology,Linzhou Esophageal Cancer Hospital,Linzhou 456550,China [7]Department of Oncology,Nanyang Central Hospital,Nanyang 473000,China [8]Department of Thoracic Surgery,Xinxiang Central Hospital,Xinxiang 453000,China [9]Department of Oncology,Anyang District Hospital,Anyang 455000,China [10]Department of Thoracic Surgery,Linzhou Center Hospital,Linzhou 456550,China [11]Department of Oncology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China [12]Department of Gastroenterology,The Second Affiliated Hospital of Nanyang Medical College,Nanyang 473000,China [13]Department of Pathology,Anyang Tumor Hospital,Anyang 455000,China [14]Department of Radiotherapy,The Affiliated Cancer Hospital of Zhengzhou University(Henan Cancer Hospital),Zhengzhou 450000,China [15]Department of Pathology,The Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China [16]Department of Pathology,Hebei Provincial Cixian People's Hospital,Cixian 056500,China

出　　处：《Cancer Biology & Medicine》2020年第1期218-226,共9页癌症生物学与医学（英文版）

基　　金：supported by the National Key R&D Program “Precision Medicine” of China (Grant No. 2016YFC0901403);the Major Science and Technology Projects of Henan Province (Grant No. 16110031 1300);the Doctoral Team Foundation of the First Affiliated Hospital of Zhengzhou University (Grant No. 2016-BSTDJJ-03);the National Natural Science Foundation of China (Grant No. 81872032, U1804262);the State Key Laboratory of Esophageal Cancer Prevention and Treatment (Grant No. Z2020-0010)。

摘　　要：Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients.

关 键 词：Cervical esophageal cancer SURVIVAL ESOPHAGECTOMY RADIOCHEMOTHERAPY 

分 类 号：R735.1[医药卫生—肿瘤]