胶质母细胞瘤中ERLIN2的表达情况及其与预后的相关性  

ERLIN2 expression in glioblastoma and its correlation with prognosis

作　　者：柳泽彬 肖铮铮 邵政 范波[1] Liu Zebin;Xiao Zhengzheng;Shao Zheng;Fan Bo(Department of Clinical Medicine,Henan University of Science and Technology,Department of Neurosurgery,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院,河南科技大学第一附属医院神经外科,洛阳471003

出　　处：《国际生物医学工程杂志》2020年第1期36-40,共5页International Journal of Biomedical Engineering

摘　　要：目的分析内质网脂质筏关联蛋白2(ERLIN2)在胶质母细胞瘤组织中的表达,并分析其表达与胶质母细胞瘤患者临床病理特征和预后的相关性。方法使用TCGA数据库分析ERLIN2的mRNA在胶质母细胞瘤中的表达水平。通过KM-plotter分析ERLIN2表达与胶质母细胞瘤患者预后的相关性。通过免疫组化染色确定ERLIN2蛋白在78例胶质母细胞瘤组织中的表达水平。根据肿瘤组织中的ERLIN2表达水平将样本分为高表达与低表达组。收集患者临床病理资料,包括年龄、性别、肿瘤偏侧性、复发、异柠檬酸脱氢酶(IDH)突变,进一步分析ERLIN2蛋白与临床病理特征的相关性。结果ERLIN2的mRNA在胶质母细胞瘤中显著高表达,ERLIN2高表达的患者的总生存率较低,提示不良预后。免疫组化及临床病理分析结果表明,ERLIN2蛋白在胶质母细胞瘤中显著高表达,其表达水平与肿瘤复发显著相关。结论ERLIN2蛋白在胶质母细胞瘤组织中显著高表达,其表达水平与胶质母细胞瘤的临床病理特征及不良预后相关,提示ERLIN2可作为潜在的胶质母细胞瘤预后预测因子。Objective To analyze the expression of endoplasmic reticulum lipid raft-associated protein 2(ERLIN2)in glioblastoma tissues,and to analyze its correlation with the clinicopathological features and prognosis of patients with glioblastoma.Methods The TCGA database was used to analyze the expression level of ERLIN2 mRNA in glioblastoma.KM-plotter was used to analyze the correlation between ERLIN2 expression and prognosis in patients with glioblastoma.The expression level of ERLIN2 protein in 78 cases of glioblastoma tissue was determined by immunohistochemical staining,and then the tissue samples were divided into high expression and low expression groups according to the ERLIN2 expression level.The clinical and pathological data of patients were collected,including age,gender,tumor laterality,recurrence,isocitrate dehydrogenase(IDH)mutation,and the correlation between ERLIN2 protein and clinicopathological characteristics was further analyzed.Results The mRNA of ERLIN2 was significantly overexpressed in glioblastoma,and the overall survival rate of patients with high ERLIN2 expression was low,suggesting a poor prognosis.The results of immunohistochemistry and clinicopathological analysis showed that ERLIN2 protein was significantly overexpressed in glioblastoma,and its expression level was significantly related to tumor recurrence.Conclusions ERLIN2 protein is significantly overexpressed in glioblastoma tissues,and its expression level is related to the clinicopathological characteristics and poor prognosis,suggesting that ERLIN2 can be used as a potential prognostic factor for glioblastoma.

关 键 词：胶质母细胞瘤 内质网脂质筏关联蛋白2 免疫组化 肿瘤复发 预后 

分 类 号：R739.4[医药卫生—肿瘤]