Demyelinating polyneuropathy and lymphoplasmacytic lymphoma coexisting in 36-year-old man:A case report  

作　　者：Lesia Rozlucka Elzbieta Semik-Grabarczyk Marta Pietrukaniec Agnieszka Zak-Golab Malgorzata Grabarczyk Sebastian Grosicki Michal Holecki 

机构地区：[1]Department of Internal Medicine,Allergology and Clinical Immunology,Faculty of Medical Sciences in Zabrze,Medical University of Silesia,Katowice 40-752,Poland [2]Department of Internal Medicine,Autoimmune and Metabolic Diseases,Faculty of Medical Sciences in Katowice,Medical University of Silesia,Katowice 40-752,Poland [3]Student Scientific Society at the Department of Internal Medicine,Autoimmune and Metabolic Diseases,Faculty of Medical Sciences in Katowice,Medical University of Silesia,Katowice 40-752,Poland [4]Department of Hematology and Cancer Prevention,Faculty of Health Sciences in Bytom,Medical University of Silesia,Bytom,41-902,Poland

出　　处：《World Journal of Clinical Cases》2020年第12期2566-2573,共8页世界临床病例杂志

摘　　要：BACKGROUND Lymphoplasmacytic lymphoma is a rare non-Hodgkin’s lymphoma,occurring mostly in the elderly.It develops slowly and leads to malignant proliferation of lymphoid line cells in the bone marrow,lymph nodes and spleen.It may also affect nerve roots and meninges;some patients develop sensorimotor polyneuropathy which may precede general symptoms of lymphoma.CASE SUMMARY We present a case of a 36-year-old man diagnosed in 2012 with chronic inflammatory demyelinating polyneuropathy(CIDP),then he was hospitalized in 2019 due to progressive symptoms of heart failure and significant weight loss over the previous four months.Based on clinical and laboratory findings a diagnosis of lymphoplasmacytic lymphoma was suspected and confirmed by bone marrow flow cytometry.There was no improvement in the results of laboratory tests and the patient's condition after immediate implementation of chemotherapy.Patient died on the fifth day of treatment.CONCLUSION While CIDP and malignant disease co-occurrence is rare,it should be suspected and investigated in patients with atypical neuropathy symptoms.

关 键 词：Lymphoplasmacytic lymphoma Chronic inflammatory demyelinating polyneuropathy POLYNEUROPATHY Paraneoplastic neuropathy AUTOIMMUNITY Case report 

分 类 号：R73[医药卫生—肿瘤]