The research idea of Xuebijing injection in influencing severe pneumonia-pulmonary fibrosis with blood stasis syndrome evolution by inhibiting inflammation, endotoxin and dispersing blood stasis  

作　　者：Rui Zheng Chengyu Li Ping Wang Min Li Pengqian Wang Changming Zhong Jianxun Wang Hongcai Shang 

机构地区：[1]Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,China [2]Tianjin Chase Sun Pharmaceutical Co.,Ltd,Tianjin,China [3]School of Life Sciences,Beijing University of Chinese Medicine,Fangshan District,Beijing,China [4]Department of Cardiology,Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing,China [5]Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,China

出　　处：《TMR Modern Herbal Medicine》2020年第2期113-119,共7页TMR现代中药

基　　金：the second batch of“Ten thousand plan”-National high level talents special support plan(W02020052).

摘　　要：Severe pneumonia is one of the most serious infectious diseases.Delayed intervention may lead to pulmonary fibrosis,which greatly threatens people’s life and health.Blood stasis syndrome is an important underlying syndrome throughout the evolution of severe pneumonia-pulmonary fibrosis.Xuebijing injection(XBJ)was developed under the theoretical system of“Three syndromes and three methods”,demonstrating a good efficacy in treating severe pneumonia and pulmonary fibrosis due to its effect of removing blood stasis and dispersing toxins.Previous studies have shown that XBJ can protect vascular endothelial function,improve coagulation function and regulate immunity by inhibiting inflammatory.Hence,the research hypothesis is put forward that XBJ treats blood stasis syndrome by removing blood stasis and dredging blood vessels,to inhibit the disease progress of severe pneumonia to pulmonary fibrosis.Further researches are need to confirm the function and explore the mechanism of XBJ.

关 键 词：XUEBIJING injection Severe PNEUMONIA Pulmonary fibrosis Blood STASIS syndrome COAGULATION 

分 类 号：R57[医药卫生—消化系统]