多肽作为抗肿瘤纳米药物中作用片段的研究进展  

Research Progress of Peptides as Action Fragments in Anti-tumor Nanodrugs

作　　者：郭鑫昊 禄秀娟 潘杰[1] 万冬[1] Guo Xinhao;Lu Xiujuan;Pan Jie;Wan Dong(School of Chemistry and Chemical Engineering,Tiangong University,Tianjin,300387)

机构地区：[1]天津工业大学化学与化工学院,天津300387

出　　处：《当代化工研究》2020年第14期140-143,共4页Modern Chemical Research

摘　　要：近年来,由于多肽的体内降解能力强、代谢终产物无毒等优势,以及多肽类纳米药物的结构多样性,基于肽的抗肿瘤纳米材料逐渐成为生物医学、材料学等领域的研究热点,在抗癌领域中有着良好的应用前景。为了更好地对抗肿瘤纳米材料中多肽的功能进行概述,对常见的多肽嵌段进行了分类介绍,总结了目前国内外基于肽的抗癌纳米载体的研究进展及发展现状,同时也就多肽的作用机制和影响因素进行了分析和探讨。In recent years,peptide-based anti-tumor nanomaterials have attracted much attention in the fields of biomedicine and materials science because of the strong degradation ability of in vivo,the end products of metabolism are non-toxic of peptides,and the structural diversity of peptide nanomedicines,have a good application prospect in the field of anti-cancer.In order to better understand the function of peptides in tumor nanomaterials,the classification of common peptide blocks were introduced,the research progress and development status of peptide-based anti-cancer nanocarriers at home and abroad were summarized.Meanwhile,the response mechanism and influencing factors of peptides were analyzed and discussed.

关 键 词：多肽 药物传递 抗肿瘤 纳米材料 

分 类 号：R[医药卫生]