Acute lymphoblastic leukemia in a β-thalassemia intermedia child: A case report  

作　　者：Laila M Sherief Esmael Goneim Naglaa M Kamal Amr Ibraheim Fuad Alsofiani Abdulraouf Alawur 

机构地区：[1]Department of Pediatric Hematology and Oncology,Faculty of Medicine,Zagazig University,Zagazig 44511,Egypt [2]Department of Pediatrics,Faculty of Medicine,Zagazig University,Zagazig 44511,Egypt [3]Department of Pediatric Oncology,Tanta Cancer Institute,Tanta 00202,Egypt [4]Department of Pediatrics and Pediatric Hepatology,Faculty of Medicine,Cairo University,Cairo 21121,Egypt [5]Fuad A alsofiani,Abdulraouf H Alawur,Department of Pediatrics,Alhada Armed Forces Hospital,Taif 00966,Saudi Arabia

出　　处：《World Journal of Clinical Pediatrics》2020年第1期1-6,共6页世界临床儿科杂志

摘　　要：BACKGROUNDβ-thalassemia intermedia(βTI)is one of the hemoglobinopathies.It constitutes 10%ofβ-thalassemia cases yet being associated with a better quality of life thanβ-thalassemia major(βTM).CASE SUMMARY We recently reported the first case of acute lymphoblastic leukemia(ALL)from Egypt in a child withβTM,and we herein report the first case of ALL from Egypt in a child withβTI.In this report,literature was reviewed for cases of malignancies associated withβTI and the possible factors underling the relationship between the two entities.CONCLUSION We stress that physicians should have a high index of suspicion of malignancies in thalassemia patients if they present with any suggestive symptoms or signs.

关 键 词：Acute lymphoblastic leukemia Thalassemia intermedia Children MALIGNANCIES Iron overload HYDROXYUREA Case report 

分 类 号：R733.71[医药卫生—肿瘤] R725.5[医药卫生—临床医学]