MAPT基因突变额颞叶痴呆tau蛋白靶向正电子发射计算机断层显像技术研究进展  

Research progress of tau pet in frontotemporal dementia with MAPT gene mutation

作　　者：孔雨 武力勇[1] KONG Yu;WU Liyong(Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院神经内科,北京100053

出　　处：《实用医学杂志》2020年第15期2157-2160,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:81971011)。

摘　　要：额颞叶痴呆(frontotemporal dementia,FTD)是以精神行为异常、言语功能损害和执行功能障碍为特点的神经系统退行性变疾病。MAPT基因突变所导致脑内异常tau蛋白沉积是其致病机制之一。随着正电子发射计算机断层显像(positron emission tomography,PET)的发展,使得利用以tau蛋白为靶点的选择性PET影像技术在活体水平检测脑内tau蛋白病变成为可能,这对进一步探究额颞叶痴呆发病机制、早期诊断及靶向治疗等起到重要作用。但由于病理性tau蛋白存在异质性,目前对于tau PET影像技术能否准确的反映各型tau蛋白的沉积尚无定论。本文就MAPT基因突变FTD tau PET研究现状展开相关讨论。Frontotemporal dementia(FTD) is a neurodegenerative disorder characterized by progressive changes in behavior,personality,language,and executive function.The desposition of tauopathy caused by MAPT mutation is one of the underlying pathogenic mechanisms of FTD.The advent of positron emission tomography(PET) makes it possible to detect the burden and distribution of tauopathy in brain in vivo,which plays an important role in the investigation of the pathogenic mechanism,early diagnosis and targeted therapy of FTD.However,due to the heterogeneity of tauopathy,the accuracy of tau PET is still controversial.Here,we discuss the research status of tau PET of FTD that caused by MAPT mutation in this article.

关 键 词：额颞叶痴呆 MAPT基因 TAU tau PET 

分 类 号：R742[医药卫生—神经病学与精神病学]