乳腺导管原位癌浸润机制的研究进展  

Research Advances in Infiltration Mechanism of Ductal Carcinoma in Situ

作　　者：张雪[1] 薛美玲 段秀庆[1] ZHANG Xue;XUE Meiling;DUAN Xiuqing(Department of Breast Surgery,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院乳腺外科,哈尔滨150001

出　　处：《医学综述》2020年第14期2780-2784,共5页Medical Recapitulate

摘　　要：乳腺导管原位癌(DCIS)是可以治愈的早期癌症。近年来,人们一直认为DCIS是浸润性导管癌(IDC)的非专一性前体,识别出哪些DCIS具有进展能力,并发掘其进展机制是该领域的重要研究方向。肿瘤微环境被认为是肿瘤进展的重要参与者。在疾病发展过程中,构成微环境的细胞中存在显著的基因表达和表观遗传学改变,可作为治疗的生物标志物和靶点。此外,通过分析DCIS和IDC的基因表达谱发现两者具有很高的基因组相似性,但仍检测出一些质的差异,表明在某些样本中发生了从DCIS到IDC的进展。Ductal carcinoma in situ(DCIS)is a curable early form of cancer.In recent years,it has been accepted that DCIS constitutes a non-obligate precursor of invasive ductal carcinoma(IDC).However,it is still an important research direction in this field to identify which DCIS has the progressive potential and explore the progress mechanism.The microenvironment of cancer is considered to be an important player in tumor progression.In the process of disease development,there are significant gene expression and epigenetic changes in the cells that make up the microenvironment,which can serve as biomarkers and targets for treatment.In addition,through the analysis of gene expression profiles of DCIS and IDC,it is found they have high genomic similarity while some qualitative differences were still detected,which indicated that progress from DCIS to IDC occurred in some samples.

关 键 词：导管原位癌 浸润性导管癌 浸润机制 肿瘤微环境 表观遗传学 基因变异 

分 类 号：R737.9[医药卫生—肿瘤]