cAMP/PKA pathway and mitochondrial protection in oxidative stress-induced optic nerve head astrocytes  

作　　者：Keun-Young Kim Won-Kyu Ju 

机构地区：[1]National Center for Microscopy and Imaging Research and Department of Neurosciences,University of California San Diego,La Jolla,CA,USA [2]Hamilton Glaucoma Center and Shiley Eye Institute,The Viterbi Family Department of Ophthalmology,University of California San Diego,La Jolla,CA,USA

出　　处：《Neural Regeneration Research》2021年第1期108-109,共2页中国神经再生研究（英文版）

摘　　要：Oxidative stress and cyclic adenosine 3′,5′-monophosphate(cAMP)/protein kinase A(PKA)pathway in the optic nerve head astrocytes:Glaucoma is a leading cause of blindness worldwide in individuals 60 years of age and older.Despite the widely appreciated disease relevance of structural and functional abnormalities of astrocyte in the optic nerve head(ONH)that is associated with retinal ganglion cell(RGC)axon degeneration,the molecular mechanisms underlying astrocyte dysfunction in glaucomatous ONH degeneration are poorly understood.Oxidative stress is strongly linked to glaucoma pathogenesis,and astrocytes are the responsible cell type that is mostly related to oxidative stress and glaucomatous ONH degeneration.

关 键 词：OXIDATIVE stress DEGENERATION 

分 类 号：R775[医药卫生—眼科]