Neuroprotective effects of metalosalen complexes against oxidative stress  

作　　者：Lara Rouco Marcelino Maneiro 

机构地区：[1]Departamento de Química Inorgánica,Universidade de Santiago de Compostela,Lugo,Spain

出　　处：《Neural Regeneration Research》2021年第1期121-122,共2页中国神经再生研究（英文版）

摘　　要：Neurodegenerative diseases and oxidative stress:During the metabolic processes,O2 can accept unpaired electrons to form superoxide radical species(O2^·–),which are able to generate hydrogen peroxide(H2O2)with a fast dismutation,therefore increasing the hydroxyl radical(HO^·)levels.These species and other radicals(·OOH,ROO^·,RO^·,CO3^·–),which can be produced through a sequence of reactions,constitute the designated reactive species of oxygen(ROS).Oxidative stress is caused by a disequilibrium between the ROS produced and the antioxidant defence against them(catalase enzymes,superoxide dismutase(SOD)and glutathione peroxidases,in addition to other non-enzymatic antioxidants,such asα-tocopherol,ascorbic acid and carotenes).

关 键 词：OXIDATIVE COMPLEXES RADICAL 

分 类 号：R741[医药卫生—神经病学与精神病学]