Inosine: a novel treatment for sciatic nerve injury  

作　　者：Fellipe Soares dos Santos Cardoso Ana Maria Blanco Martinez Fernanda Martins de Almeida 

机构地区：[1]Laboratório de Neurodegeneração e Reparo–Departamento de Anatomia Patológica–Hospital Universitário Clementino Fraga Filho HUCFF/Universidade Federal do Rio de Janeiro,Rio de Janeiro,Brazil [2]Instituto de Ciências Biomédicas–ICB/Universidade Federal do Rio de Janeiro,Rio de Janeiro,Brazil

出　　处：《Neural Regeneration Research》2021年第1期127-128,共2页中国神经再生研究（英文版）

摘　　要：Trauma to the peripheral nervous system often results in loss of motor and sensory functions of the affected area of the body,leading to a series of functional impairments(Allodi et al.,2012).Injuries to peripheral nerves initiate a series of complex events,known as Wallerian degeneration,which allows the injured axons to regenerate and reinnervate their targets(Allodi et al.,2012).Damage to a nerve induces multiple alterations,which include:axonal degeneration,breakdown of myelin sheath,Schwann cells(SC)proliferation and conversion to a repair phenotype which express cytokines and chemokines that allow the infiltration and activation of macrophages(Mietto et al.,2015;Jessen and Mirsky,2016).

关 键 词：al. DEGENERATION alterations 

分 类 号：R745[医药卫生—神经病学与精神病学]