Oxcarbazepine monotherapy in children with benign epilepsy with centrotemporal spikes improves quality of life  被引量:11

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作  者:Wan-Ting Liu Xiu-Xian Yan Da-Zhi Cheng Han-Zi Zhang Ning Ding Ke-Ming Xu Xin-Lin Zhou Qian Chen 

机构地区:[1]Department of Neurology,Capital Institute of Pediatrics,Beijing 100020,China [2]National Key Laboratory of Cognitive Neuroscience and Learning,Institute of Cognitive Neuroscience and Learning,Beijing Normal University,Beijing 100020,China

出  处:《Chinese Medical Journal》2020年第14期1649-1654,共6页中华医学杂志(英文版)

基  金:This work was supported by the grants from the National Key Research and Development Program of China(Nos.2016YFC0905100 and 2016YFC1000504);the CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2016-I2M-1-002);Beijing Municipal Science&Technology Commission(No.Z171100000417020).

摘  要:Background:Benign epilepsy with centrotemporal spikes(BECTS)is the most common type of childhood idiopathic focal epilepsy.BECTS is associated with pervasive cognitive deficits and behavior problems.While seizures can be easily controlled,it is crucial to select anti-epileptic drugs that do not impair cognition,do not cause psychosocial effects,and improve the quality of life.Previous studies showed effects of oxcarbazepine(OXC)monotherapy on the cognitive and psychosocial profiles of patients with BECTS.Here,we studied the effects of OXC monotherapy on the neuropsychologic profiles and quality of life in patients with BECTS in China.Methods:Thirty-one patients aged 6 to 12 years newly diagnosed with BECTS were recruited.A psychometric assessment was performed before and during the follow-up of OXC monotherapy with Cognitive Computerized Task Battery,Depression SelfRating Scale for children,Screen for Child Anxiety Related Emotional Disorders,and Quality of Life in Epilepsy-31(QOLIE-31).The results of the assessments were compared to explore the effect of OXC monotherapy in patients with BECTS.Results:Thirty children with BECTS completed the study.Five of ten cognitive test scores improved after treatment via OXC monotherapy,including visual tracing(F=14.480,P<0.001),paired associated learning(language)(F=6.292,P<0.001),paired associated learning(number)(F=9.721,P<0.05),word semantic(F=6.003,P<0.05),and simple subtraction(F=6.229,P<0.05).Of the neuropsychology data concerning the quality of life,statistically significant improvements were observed in emotion(F=4.946,P<0.05),QOLIE-social(F=5.912,P<0.05),and QOLIE-total(F=14.161,P<0.001).Conclusions:OXC is safe and does not impair neuropsychologic functions,with no obvious mood burden on children with BECTS.Most importantly,OXC has positive impacts on children’s perception of quality of life,especially in terms of happiness and life satisfaction.

关 键 词:EPILEPSY Cognition Psychosocial difficulties Cognitive function Benign epilepsy with centro-temporal spikes 

分 类 号:R742.1[医药卫生—神经病学与精神病学]

 

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