副溶血性弧菌耐热性直接溶血素(TDH)的研究进展  

Advances in research on thermostable direct hemolysin (TDH) of Vibrio parahaemolyticus

作　　者：檀利军 王敬敬[1,2,3] 石千黛 刘海泉 赵勇[1,2,3] Lijun Tan;Jingjing Wang;Qiandai Shi;Haiquan Liu;Yong Zhao(College of Food Science and Technology,Shanghai Ocean University,Shanghai 201306,China;Shanghai Engineering Research Center of Aquatic-Product Processing&Preservation,Shanghai 201306,China;Quality&Safety Risk Assessment for Aquatic Products on Storage and Preservation(Shanghai),Ministry of Agriculture,Shanghai 201306,China)

机构地区：[1]上海海洋大学食品学院,上海201306 [2]上海水产品加工贮藏工程技术研究中心,上海201306 [3]农业农村部水产品贮藏保鲜质量安全风险评估实验室(上海),上海201306

出　　处：《微生物学报》2020年第8期1563-1573,共11页Acta Microbiologica Sinica

基　　金：国家自然科学基金(31671779,31972188);国家重点研发计划(2018YFC1602205);上海市科技兴农项目(沪农科推字2017第4-4号);上海市教育委员会科研创新计划(2017-01-07-00-10-E00056)。

摘　　要：副溶血性弧菌(Vibrio parahaemolyticus)是海产品中一种常见的食源性致病菌,常导致水产养殖动物患病或者引起食物中毒。耐热性直接溶血素(thermotolerant direct hemolysin,TDH)是副溶血性弧菌最为重要的致病因子之一。本文围绕tdh基因在弧菌属中的广泛分布与传播、tdh基因的多样性及其表达调控、TDH的蛋白结构及其生物活性进行了综述,并对未来TDH的研究方向进行了展望。旨在进一步了解由副溶血性弧菌感染所引起的病症,为预防副溶血性弧菌的感染和临床治疗提供理论支撑。Vibrio parahaemolyticus is a widely distributed foodborne pathogen in seafood,often leading to diseases in aquaculture animals or food poisoning for human beings.Thermotolerant direct hemolysin(TDH)is one of the most important virulence factors of V.parahaemolyticus.This article systematically reviews the widespread distribution,spreading,the diversity and expression regulation of tdh gene,as well as the structure,biological activity and promising research directions of TDH protein.The article aims to deeply understand the symptoms caused by V.parahaemolyticus infection,and hence to provide theoretical support for the prevention and clinical treatment of V.parahaemolyticus infection.

关 键 词：副溶血性弧菌 耐热性直接溶血素 tdh基因 结构 表达调控 生物活性 

分 类 号：R378[医药卫生—病原生物学]