The antiatherogenic function of kallistatin and its potential mechanism  

作　　者：Gang Wang Jin Zou Xiaohua Yu Shanhui Yin Chaoke Tang 

机构地区：[1]Department of Cardiology,The First Affiliated Hospital of University of South China,Institute of Cardiovascular Disease,Key Laboratory for Atherosclerology of Hunan Province,Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease,Medical Research Experiment Center,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,Hengyang Medical College,University of South China,Hengyang 421001,China [2]Institute of Clinical Medicine,The Second Affiliated Hospital of Hainan Medical University,Haikou 570100,China

出　　处：《Acta Biochimica et Biophysica Sinica》2020年第6期583-589,共7页生物化学与生物物理学报（英文版）

基　　金：the grants from the National Natural Science Foundation of China(No.81770461);the Education Department of Hunan Province(No.17C1390).

摘　　要：Atherosclerosis is the pathological basis of most cardiovascular diseases,the leading cause of morbidity and mortality worldwide.Kallistatin,originally discovered in human serum,is a tissuekallikrein-binding protein and a unique serine proteinase inhibitor.Upon binding to its receptor integrin p3,lipoprotein receptor-related protein 6,nucleolin,or Krüppel-like factor 4,kallistatin can modulate various signaling pathways and affect multiple biological processes,including angioge esis,inflammatory response,oxidative stress,and tumor growth.Circulating kallistatin levels are sign ificantly decreased in patie nts with coronary artery disease and show an in verse correlati on with its severity.Importantly,both in vitro and in vivo experime nts have dem on strated that kallistatin reduces atherosclerosis by inhibiting vascular in flammation,antagonizing endothelial dysfunction,and improving lipid metabolism.Thus,kallistatin may be a novel biomarker and a promising therapeutic target for atherosclerosis-related diseases.In this review,we focus on the antiatherogenic function of kallistatin and its potential mechanism.

关 键 词：KALLISTATIN Krüppel-like factor 4 INFLAMMATION ATHEROSCLEROSIS 

分 类 号：R543.5[医药卫生—心血管疾病]