血同型半胱氨酸、纤维蛋白原、D-二聚体联合检测在急性脑梗死诊断中的临床意义  

Clinical significance of combined detection of homocysteine,fibrinogen and D⁃dimer in the diagnosis of acute cerebral infarction

作　　者：钟可文 孙华 赵玉环[1] 骆惠华 袁中青 梁丽华[1] 罗东[1] ZHONG Kewen;SUN Hua;ZHAO Yuhuan;LUO Huihua;YUAN Zhongqing;LIANG Lihua;LUO Dong(Department of Clinical Laboratory,Chancheng Branch,Foshan First People’s Hospital,Foshan,Guangdong 528061,China)

机构地区：[1]佛山市第一人民医院禅城医院检验科,广东佛山528061

出　　处：《安徽医药》2020年第9期1803-1805,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨血同型半胱氨酸(Hcy)、纤维蛋白原(FIB)、D-二聚体(D-D)联合检测在急性脑梗死病人诊断中的临床意义。方法选择2017年6月至2019年3月于佛山市第一人民医院禅城医院就诊的急性脑梗死病人100例为研究组,根据病情的进展与演变分为非进展组(n=59)与进展组(n=41),并选择同期于该院体检的健康人100例为对照组,比较各组Hcy、FIB、D-D水平差异。结果研究组病人的Hcy为(15.11±5.69)μmol/L、FIB为(5.39±1.15)g/L、D-D为(2.63±1.29)mg/L,对照组病人的Hcy为(6.05±2.18)μmol/L、FIB为(2.88±0.57)g/L、D-D为(0.28±0.14)mg/L,研究组病人的Hcy、FIB及D-D显著高于对照组(P<0.001)。进展组病人的Hcy为(21.60±7.05)μmol/L、FIB为(6.68±2.13)g/L、D-D为(5.01±1.42)mg/L,非进展组病人的Hcy为(12.53±3.44)μmol/L、FIB为(4.53±1.90)g/L、D-D为(1.85±1.17)mg/L,进展组中的Hcy、FIB及D-D显著高于非进展组(P<0.001)。结论 Hcy、FIB、D-D与急性脑梗死的发生、发展具有密切联系,联合检测可辅助判断急性脑梗死病人的病情,有利于及时诊断治疗,改善病人预后。Objective To explore the clinical significance of combined detection of homocysteine(Hcy),fibrinogen(FIB)and D⁃dimer(D⁃D)in the diagnosis of patients with acute cerebral infarction.Methods 100 patients with acute cerebral infarction who were admitted to Chancheng Hospital of Foshan First People’s Hospital from June 2017 to March 2019 were selected as the study group.They were divided into non⁃progressive group(n=59)and progress Group(n=41)according to the progress and evolution of the disease.100 healthy people who were examined in the hospital during the same period were selected as the control group.The difference of Hcy,FIB and DD between the groups were compared.Results The Hcy of the study group was(15.11±5.69)μmol/L,FIB was(5.39±1.15)g/L,DD was(2.63±1.29)mg/L,and the control group had Hcy of(6.05±2.18)μmol/L,FIB was(2.88±0.57)g/L,DD was(0.28±0.14)mg/L.The levels of Hcy,FIB and DD of the study group were significantly higher than those of the control group(P<0.001).The Hcy of the patients in the progression group was(21.60±7.05)μmol/L,FIB was(6.68±2.13)g/L,DD was(5.01±1.42)mg/L,and the Hcy of the non⁃progressive group was(12.53±3.44)μmol./L,FIB was(4.53±1.90)g/L,DD was(1.85±1.17)mg/L.The levels of Hcy,FIB and DD of the progression group were significantly higher than those of the non⁃pro⁃gressive group(P<0.001).Conclusion Hcy,FIB,D⁃D are closely related to the occurrence and development of acute cerebral in⁃farction.Combined detection can assist in judging the condition of patients with acute cerebral infarction,which is conducive to timely diagnosis and treatment and improves prognosis of patients.

关 键 词：脑梗死 高同种半胱氨酸血症 早期诊断 纤维蛋白原 D-二聚体 

分 类 号：R743.33[医药卫生—神经病学与精神病学]