长链非编码RNA CCAT1在妇科肿瘤中的研究进展  

Research Progress of Long Non-Coding RNA CCAT1 in Gynecologic Oncology

作　　者：郭学旺 徐燕颖(审校)[1] GUO Xue-wang;XU Yan-ying(The Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院,300211

出　　处：《国际妇产科学杂志》2020年第4期451-455,共5页Journal of International Obstetrics and Gynecology

摘　　要：妇科恶性肿瘤的发病率呈逐年上升趋势,而改善其预后的关键为早期诊断、早期治疗。在未来医学发展中,疾病的诊断和治疗必将定位于基因水平。目前,关于非编码RNA对细胞表型调控机制的研究正逐渐展开。自2012年长链非编码RNA(lncRNA)结肠癌相关转录因子1(CCAT1)在结直肠癌中的异常表达被发现以来,其在多种其他恶性肿瘤中的调控作用陆续被研究。目前对lncRNA作用机制的研究以lncRNA与微小RNA(miRNA)的相互作用为主,lncRNA通过miRNA调控的下游效应分子的致瘤作用参与恶性肿瘤的发生、发展。综述CCAT1在妇科恶性肿瘤中的作用机制,分析其研究现状及未来发展。The incidence of gynecological malignant tumor is increasing year by year,and the key to improve its prognosis is early diagnosis and early treatment.In the future development of medicine,the diagnosis and treatment of diseases will be located at the level of gene.At present,the research on the regulation mechanism of non-coding RNA on cell phenotype is gradually unfolding.Since the abnormal expression of long non-coding RNA(lncRNA)colon cancer associated transcription 1(CCAT1)in colorectal cancer was found in 2012,its regulatory role in a variety of other malignant tumors has been studied in succession.At present,studies on the mechanism of lncRNA mainly focus on the interactions between lncRNA and miRNA,and lncRNA is associated with the occurrence and development of malignant tumors through the tumorigenic effect of the downstream effectors regulated by miRNA.This paper reviews the mechanism of CCAT1 in gynecological cancer,and analyze research status and future development.

关 键 词：RNA 长链非编码 结直肠肿瘤 转录因子 生殖器肿瘤 女(雌)性 生物标记 肿瘤 计算生物学 实时聚合酶链反应 

分 类 号：R737.3[医药卫生—肿瘤]