Circular RNA and its potential as prostate cancer biomarkers  

作　　者：Dwayne Tucker Wei Zheng Da-Hong Zhang Xuesen Dong 

机构地区：[1]Department of Urologic Sciences,University of British Columbia,Vancouver,BC V6H 3Z6,Canada [2]Department of Urology,Zhejiang Provincial People's Hospital,Hangzhou 310024,Zhejiang Province,China

出　　处：《World Journal of Clinical Oncology》2020年第8期563-572,共10页世界临床肿瘤学杂志（英文版）

摘　　要：Advancing knowledge of the transcriptome has revealed that circular RNAs(circRNAs)are widely expressed and evolutionarily conserved molecules that may serve relevant biological roles.More interesting is the accumulating evidence which demonstrates the implication of circRNAs in diseases,especially cancers.This revelation has helped to form the rationale for many studies exploring their utility as clinical biomarkers.CircRNAs are highly stable due to their unique structures,exhibit some tissue specificity,and are enriched in exosomes,which facilitate their detection in a range of body fluids.These properties make circRNAs ideal candidates for biomarker development in many diseases.This review will outline the discovery,biogenesis,and proposed functions of circRNAs.

关 键 词：Circular RNA RNA splicing Prostate cancer BIOMARKER Cell-free RNA 

分 类 号：R737.25[医药卫生—肿瘤]