Multidisciplinary treatment of life-threatening hemoptysis and paraplegia of choriocarcinoma with pulmonary,hepatic and spinal metastases:A case report  

作　　者：Yuan-Yuan Lin Yang Sun Yu Jiang Bao-Zhi Song Li-Juan Ke 

机构地区：[1]Department of Gynecology,Fujian Cancer Hospital,Affiliated Cancer Hospital of Fujian Medical University,Fuzhou 350014,Fujian Province,China [2]Department of Gynecology,Shengli Clinical Medical College of Fujian Medical University,Fujian Provincial Hospital,Fuzhou 350001,Fujian Province,China

出　　处：《World Journal of Clinical Cases》2020年第17期3867-3874,共8页世界临床病例杂志

摘　　要：BACKGROUND Although choriocarcinoma is thought to be a malignancy curable by chemotherapy,there remain difficult and challenging problems in cases with high prognostic scores or extensive metastases,for which the treatment is limited.Particularly,chemotherapy in combination with other treatments offers promising therapeutic potential for these cases.CASE SUMMARY We present the case of a 40-year-old female patient who suffered from lifethreatening hemoptysis and paraplegia due to choriocarcinoma with pulmonary,hepatic and spinal metastases.The patient successfully recovered after multidisciplinary treatment consisting of 21 cycles of intravenous chemotherapy,radiofrequency ablation of multiple hepatic metastases,intensity-modulated radiation therapy for spinal metastases and routine physiotherapy.To our knowledge,it is the first reported case of recovery from pulmonary,hepatic and spinal metastases of choriocarcinoma with no specific primary site.Moreover,this is the first reported clinical attempt on 5-d actinomycin D as primary chemotherapy in ultrahigh-risk gestational trophoblastic neoplasia.CONCLUSION The case supports the opinion that the individualized treatment of choriocarcinoma by a multidisciplinary approach can accomplish optimal therapeutic effects.

关 键 词：CHORIOCARCINOMA METASTASES Multidisciplinary treatment Case report Actinomycin D 

分 类 号：R737.33[医药卫生—肿瘤]