Nanomaterials for radiotherapeutics-based multimodal synergistic cancer therapy  

作　　者：Xi Yang Ling Gao Qing Guo Yongjiang Li Yue Ma Ju Yang Changyang Gong Cheng Yi 

机构地区：[1]Department of Medical Oncology,Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,China [2]Department of Oncology,Taizhou Peoples Hospital,Taizhou 225300,China [3]Department of Pathophysiology,West China School of Basic Medical Sciences and Forensic Medicine,Sichuan University,Chengdu 610041,China

出　　处：《Nano Research》2020年第10期2579-2594,共16页纳米研究（英文版）

基　　金：This research was supported by the Post-Doctor Research Project,West C hina Hospital,Sichuan University(No.2018HXBH032)and Sichuan Science and Technology Program(No.2019YFS0109);1.3.5 project for disciplines of excellence,West C hina Hospital,Sichuan University(No.ZYJC18035);China Postdoctoral Science Foundation(No.2019M663505);Postdoctoral Interdisciplinary Innovation Foundation,Sichuan University(No.0040204153243).

摘　　要：Over the past decade,numerous studies have attempted to enhance the effectiveness of radiotherapy(external beam radiotherapy and internal radioisotope therapy)for cancer treatment.However,the low radiation absorption coefficient and radiation resistance of tumors remain major critical challenges for radiotherapy in the clinic.With the development of nanomedicine,nanomaterials in combination with radiotherapy offer the possibility to improve the efficiency of radiotherapy in tumors.Nanomaterials act not only as radiosensitizers to enhance radiation energy,but also as nanocarriers to deliver therapeutic units in combating radiation resistance.In this review,we discuss opportunities for a synergistic cancer therapy by combining radiotherapy based on nanomaterials designed for chemotherapy,photodynamic therapy,photothermal therapy,gas therapy,genetic therapy,and immunotherapy.We highlight how nanomaterials can be utilized to amplify antitumor radiation responses and describe cooperative enhancement interactions among these synergistic therapies.Moreover,the potential challenges and future prospects of radio-based nanomedicine to maximize their synergistic efficiency for cancer treatment are identified.

关 键 词：cancer treatment RADIOTHERAPY synergistic therapies NANOMATERIALS 

分 类 号：R730.55[医药卫生—肿瘤]