103例孤独症谱系障碍儿童患龋情况及全身麻醉下牙齿治疗项目分析  

Analysis of caries experience and the dental treatments under general anesthesia in 103 cases of children with autism spectrum disorders

作　　者：吴晓冉[1] 夏斌[1] 葛立宏[1] 秦满[1] 李若竹 王渤 葛凤庆 王小竞[3] 陈旭[4] 宋光泰[5] 邵林琴[6] 汪俊[7] 邹静[8] 林居红[9] 赵玉梅[10] 梅予锋[11] 黄华[12] 曾素娟[13] Wu Xiaoran;Xia Bin;Ge Lihong;Qin Man;Li Ruozhu;Wang Bo;Ge Fengqing;Wang Xiaojing;Chen Xu;Song Guangtai;Shao Linqin;Wang Jun;Zou Jing;Lin Juhong;Zhao Yumei;Mei Yufeng;Huang Hua;Zeng Sujuan(Department of Pediatric Dentistry,Peking University School and Hospital of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology,Beijing 100081,China;Chinese Stomatological Association,Beijing 100081,China;Department of Pediatric Dentistry,School of Stomatology,The Fourth Military Medical University&State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral Diseases,Xi′an 710032,China;Department of Pediatric Dentistry,School of Stomatology,China Medical University&Liaoning Institute of Dental Research,Shenyang 110001,China;Department of Pediatric Dentistry,School of Stomatology,Wuhan University,Wuhan 430079,China;Department of Pediatric Dentistry,Jinan Stomatological Hospital,Jinan 250001,China;Department of Pediatric Dentistry,Ninth People′s Hospital,Shanghai Jiao Tong University School of Medicine&Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology&National Clinical Research Center of Stomatology,Shanghai 200011,China;Department of Pediatric Dentistry,West China Hospital of Stomatology,Sichuan University&State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases,Chengdu 610041,China;Department of Pediatric Dentistry,Stomatological Hospital of Chongqing Medical University&Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences&Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education,Chongqing 401174,China;Department of Pediatric Dentistry,School&Hospital of Stomatology,Tongji University,Shanghai Engineering Research Center of Tooth Restoration and Regeneration,Shanghai 200072,China;Department of Pediatric Denti

机构地区：[1]北京大学口腔医学院·口腔医院儿童口腔科,国家口腔疾病临床医学研究中心,口腔数字化医疗技术和材料国家工程实验室,口腔数字医学北京市重点实验室,100081 [2]中华口腔医学会,北京100081 [3]第四军医大学口腔医学院儿童口腔科,军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔疾病临床医学研究中心,西安710032 [4]中国医科大学口腔医学院儿童口腔科·辽宁省口腔医学研究所,沈阳110001 [5]武汉大学口腔医学院儿童口腔科,430079 [6]济南市口腔医院儿童口腔科,250001 [7]上海交通大学医学院附属第九人民医院儿童口腔科,上海市口腔医学重点实验室,上海市口腔医学研究所,国家口腔疾病临床研究中心,200011 [8]四川大学华西口腔医院儿童口腔科,口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,成都610041 [9]重庆医科大学附属口腔医院儿童口腔科,口腔疾病与生物医学重庆市重点实验室,重庆市高校市级口腔生物医学工程重点实验室,401174 [10]同济大学口腔医学院·附属口腔医院儿童口腔科,上海牙组织修复与再生工程技术研究中心,200072 [11]南京医科大学附属口腔医院儿童口腔科,南京医科大学口腔医学研究所,210029 [12]广西医科大学口腔医学院·附属口腔医院儿童牙病科,南宁530021 [13]广州医科大学附属口腔医院儿童口腔科·广州口腔疾病研究所·口腔医学重点实验室,510140

出　　处：《中华口腔医学杂志》2020年第9期639-646,共8页Chinese Journal of Stomatology

摘　　要：目的了解进行全身麻醉下牙齿治疗的孤独症谱系障碍(autism spectrum disorder,ASD)儿童的患龋情况及牙齿治疗内容特点。方法选择2016年4至11月参与中央财政支持的中华口腔医学会“关爱孤独症儿童口腔健康”项目,全身麻醉下进行牙齿治疗的103例ASD患者作为ASD组,病例来源于我国13家口腔专科医院,依据年龄、性别,应用分层倾向评分配比法选择2015年1月至2018年11月在相同13家口腔专科医院接受全身麻醉下牙齿治疗的97名无全身疾病的儿童作为对照(对照组),对两组儿童的龋失补牙数(decay missing filling tooth,DMFT/dmft,DMFT表示恒牙,dmft表示乳牙)和全身麻醉下牙齿治疗的内容进行统计分析。结果ASD组与对照组儿童人均DMFT/dmft[M(Q25,Q75)]分别为0(0,3)/11(8,14)和0(0,3)/9(7,13),两组差异均无统计学意义(P>0.05)。全身麻醉下人均牙齿治疗数量ASD组[13(11,15)颗]显著高于对照组[12(9,14)颗](P<0.01);ASD组儿童人均牙髓治疗数量[3(2,6)颗]显著高于对照组[2(1,4)颗](P<0.05)。结论进行全身麻醉下牙齿治疗的ASD与对照组儿童相比,DMFT/dmft差异无统计学意义,但ASD组儿童全身麻醉下牙齿治疗数量相对更多,龋坏程度相对较重。Objective To compare the caries experience and the kinds of dental treatment between children with autism spectrum disorders(ASD)and children without systemic disease who were all treated under general anesthesia.Methods Totally 103 children with ASD who received dental treatments under general anesthesia in 13 professional dental hospitals around China from April to November 2016 were included in the present study.A group of 97 children without systemic disease,according to the age,gender and application propensity score matching method,were chosen as controls,who received dental treatments under general anesthesia between January 2015 to November 2018 in the same hospitals as the children with ASD.Decay missing filling tooth(DMFT/dmft,DMFT for permanent teeth and dmft for primary teeth)indices of two groups of children and the contents of the dental treatments under general anesthesia were analyzed.Results No significant difference of DMFT/dmft index[M(Q25,Q75)]was found between children with ASD group[0(0,3)/11(8,14)]and control group[0(0,3)/9(7,13)](P>0.05).The average number of dental treatments under general anesthesia and the average number of endodontic treatment in children with ASD were 13(11,15)and 3(2,6)teeth respectively,while those in the control group were 12(9,14)and 2(1,4)teeth respectively,the differences were statistically significant(P<0.01,P<0.05).Conclusions No significant difference was found between children with ASD and the normal controls who receive dental treatments under general anesthesia in DMFT/dmft index,but the treatment needs of children with ASD is relatively higher,and their tooth decay is relatively severer.

关 键 词：儿童口腔医学 孤独症谱系障碍 麻醉 全身 龋失补指数 牙髓治疗 

分 类 号：R788.1[医药卫生—口腔医学] R749.94[医药卫生—临床医学]