The essential function of IL-33 in metabolic regulation  

作　　者：Wenping Li Yiyuan Li Jin Jin 

机构地区：[1]M0E Laboratory of Biosystem Homeostasis and Protection,and Life Sciences Institute,Zhejiang University,Hangzhou 310058,China [2]Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou 310016,China [3]Key Laboratory of Animal Virology of Ministry of Agriculture,Zhejiang University,Hangzhou 310058,China

出　　处：《Acta Biochimica et Biophysica Sinica》2020年第7期768-775,共8页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grants from the Young Scientist Foundation of NSFC(No.31822017);Zhejiang Provincial Natural Science Foundation of China(No.LR 19C080001);the National Natural Science Foundation of China(Nos.81572651 and 81771675);the Fundamental Research Funds for the Central Universities.

摘　　要：Interleukin-33(IL-33)is produced by various types of cells under physical or pathological condi-tions.As a multifunctional partner in|health and disease,current evidence reveals that IL33 also participates in several metabolic processes.IL-33 has been proven to contribute to regulating the activity of ST2+group 2 innate lymphoid cells and regulatory T cells in adipose,which leads to the shift of insulin sensitivity and glucose clearance in glucose metabolism,thermogenesis,and adipocyte beiging in adipose metabolism.In this review,we briefly summarize the biological characteristics of 1I-33 and discuss its regulatory function in glucose and adipose metabolism.By clarifying the underlying mechanism of IL33,we highlight the crostalk between immune response and metabolic processes mediated by IL33.

关 键 词：IL-33 GLUCOSE ADIPOSE METABOLISM 

分 类 号：R36[医药卫生—病理学]