Assessment of the Sensitivity and Specificity of the Established Real-time Quaking-induced Conversion(RT-QuIC)Technique in Chinese CJD Surveillance  

作　　者：XIAO Kang YANG Xue Hua ZOU Wen Quan DONG Xiao Ping SHI Qi 

机构地区：[1]State Key Laboratory for Infectious Disease Prevention and Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases(Zhejiang University),National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China [2]Center for Global Public Health,Chinese Center for Disease Control and Prevention,Beijing 102206,China [3]Wuhan Institute of Virology,Chinese Academy of Science,Wuhan 430071,Hubei China

出　　处：《Biomedical and Environmental Sciences》2020年第8期620-622,共3页生物医学与环境科学（英文版）

基　　金：Supported by Chinese National Natural Science Foundation Grants[81630062,81572048];National Key Research and Development Project[2016YFC1202700,2017YFC1200500];the State Key Laboratory of Infectious Disease Prevention and Control,China CDC[2019SKLID501 and 2019SKLID603].

摘　　要：Real-time quaking-induced conversion(RT-QuIC)assay is a newly established PrPSc-detecting method.The development of RT-QuIC improves the diagnosis of sporadic Creutzfeldt–Jakob disease(sCJD),showing good sensitivity and specificity in many countries when the method was used in cerebrospinal fluid(CSF)samples.However,in China,the sensitivity and specificity of RT-QuIC has yet to be determined due to the lack of definitive diagnosis samples.

关 键 词：diagnosis CJD CEREBROSPINAL 

分 类 号：R742.9[医药卫生—神经病学与精神病学]