精神分裂症患者语义距离与认知功能的相关性研究  

A study on the correlation between semantic distance and cognitive function in schizophrenia

作　　者：彭兴 马辛[2,3] 任艳萍 王长明[2,3] 张秀军 Peng Xing;Ma Xin;Ren Yanping;Wang Changming;Zhang Xiujun(School of Psychology,North China University of Science and Technology,Tangshan Key Laboratory of Mental Health and Cognitive Neuroscience/Tangshan Basic Innovation Team for Brain and Cognitive Function Research,Tangshan 063210;School of Mental Health,Capital Medical University,Beijing Anding Hospital,Capital Medical University,Beijing 100875;National Center for Clinical Medicine of Mental Disorders,Beijing Key Laboratory,Beijing Institute of Major Brain Diseases,Beijing 100875)

机构地区：[1]华北理工大学心理与精神卫生学院唐山市心理健康与认知神经科学重点实验室唐山市脑与认知功能研究基础创新团队,063210 [2]首都医科大学附属北京安定医院首都医科大学精神卫生学院,100875 [3]精神疾病诊断与治疗北京市重点实验室北京脑重大疾病研究院国家精神心理疾病临床医学研究中心,100875

出　　处：《中华行为医学与脑科学杂志》2020年第9期797-801,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：河北省自然科学基金项目(C2017209062);北京市医院管理中心扬帆计划(XMLX201805);北京市科技重大专项(D171100007017001)。

摘　　要：目的基于激活扩散模型和语义距离来探究精神分裂症患者词汇语义加工异常及其与认知功能、临床症状之间的关系。方法选取人口学资料匹配的被试随机分为研究组(27名)和对照组(30名)。两组分别对不同语义类别和词汇类别的词汇进行1~7等级语义距离赋值。对两组的语义距离进行重复测量方差分析,对研究组语义距离偏差与认知成套测验(MATRICS consensus cognitive battery,MCCB)分数及阳性阴性症状量表分数(positive and negative syndrome scale,PANSS)做相关性分析。结果语义距离的组别主效应具有统计学意义[F(1,55)=7.460,P=0.008,ηp2=0.981],研究组的语义距离(3.672±0.105)低于对照组语义距离(4.068±0.100)。语义类别的主效应具有统计学意义[F(1,55)=833.37,P<0.01,ηp2=0.938],相关条件下的语义距离(1.965±0.074)低于不相关条件下语义距离(5.775±0.117)。语义相关条件下,具体语义偏差和MCCB总分(r=-0.405,P=0.036)及言语学习(r=-0.569,P=0.002)呈负相关;抽象语义偏差和言语学习(r=-0.429,P=0.026)呈负相关。语义不相关条件下,具体语义偏差和MCCB总分(r=-0.597,P=0.001)、言语学习(r=-0.399,P=0.039)等维度呈负相关;抽象语义偏差和MCCB总分(r=-0.593,P=0.001)、言语学习(r=-0.285,P=0.050)等维度呈负相关。语义相关条件下,抽象语义偏差和其一般症状量表分呈正相关(r=0.448,P=0.019);语义不相关条件下,抽象词汇偏差和PANSS总分(r=0.120,P=0.010)、阴性量表分(r=0.047,P=0.030)及一般症状量表分(r=0.306,P=0.010)呈正相关。结论精神分裂症患者词汇语义距离存在异常;其语义偏差与认知功能指标、症状学指标存在相关。Objective To investigate the relationship between lexical semantic processing abnormalities and cognitive function and clinical symptoms in schizophrenia based on the activation diffusion model and semantic distance.Methods All subjects matched with demographic data were randomly divided into experiment group(n=27)and control group(n=30).The semantic distance of words of different semantic categories and lexical categories were assigned at a level of 1-7.The semantic distance between the two groups was analyzed by repeated measures of variance,and the correlation analysis was conducted on the scores of the MATRICS Consensus Cognitive Battery(MCCB)and positive and negative syndrome scale(PANSS)in the experimental group.Results The main effects of the groups in semantic distance were statistically significant(F(1,55)=7.460,P=0.008,ηp2=0.981).The semantic distance in the experimental group(3.672±0.105)was lower than that in the control group(4.068±0.100).The main effect of the semantic category was statistically significant(F(1,55)=833.37,P<0.01,ηp2=0.938),and the semantic distance in the relative condition(1.965±0.074)was lower than that in the unrelative condition(5.775±0.117).Under the relative condition,concrete semantic deviation was negatively correlated with the total score of MCCB(r=-0.405,P=0.036)and speech learning(r=-0.569,P=0.002).Abstract semantic deviation was negatively correlated with speech learning(r=-0.429,P=0.026).Under the unrelative condition,concrete semantic deviation was negatively correlated with MCCB total score(r=-0.597,P=0.001),speech learning(r=-0.399,P=0.039)and other dimensions.Abstract semantic deviation was negatively correlated with MCCB total score(r=-0.593,P=0.001)and speech learning(r=-0.285,P=0.050).Under the relative condition,the abstract semantic deviation was positively correlated with the general symptom scale score(r=0.448,P=0.019).Under the unrelative condition,abstract vocabulary semantic deviation was positively correlated with PANSS total score(r=0.120,P=0.010),

关 键 词：精神分裂症 激活扩散模型 语义距离 认知缺陷 

分 类 号：R749.3[医药卫生—神经病学与精神病学]