GLI基因在癌症中的作用及靶向治疗研究的最新进展  

Recent advances in the role and targeted therapy of GLI gene in cancer

作　　者：胡泽明 汪清志 张建康 钟佳宁 陈斌[1] HU Ze-ming;WANG Qing-zhi;ZHANG Jian-kang;ZHONG Jia-ning;CHEN Bin(The First Affiliated Hospital of Gannan Medical University;Gannan Medical University;Research Center of Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院第一附属医院 [2]赣南医学院 [3]赣南医学院科研中心,江西赣州341000

出　　处：《赣南医学院学报》2020年第8期763-770,共8页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(81760160)。

摘　　要：GLI作为Hedgehog(Hh)信号通路的关键调控因子,在各种癌症的发生发展中参与了重要的角色。本文总结了GLI在多种癌症发生中的作用及其促进肿瘤进展相关的机制,同时还讨论了GLI对肿瘤干细胞的调控功能。因此,靶向GLI抑制剂治疗可能给癌症患者带来了一种新思路。鉴于此,我们又总结了多种GLI抑制剂的作用特点以及分析了GLI抑制剂在体内外实验中的抗肿瘤效应。虽然目前只有3种GLI抑制剂进入了临床试验阶段,但未来会开展更多的临床试验来验证靶向GLI药物的临床疗效。GLI,as a key regulator of Hedgehog(Hh)signaling pathway,plays an important role in the carcinogenesis and progression of various cancers.This review summarizes the role of GLI in the tumorigenesis of a variety of malignancies and the mechanisms involved in promoting tumor progression.Meanwhile,it also discuss the regulatory functions of GLI on cancer stem cells.Therefore,targeting GLI inhibitors as a clinical therapy may bring novel insights to cancer patients.In view of these above points,it also summarizes the characteristics of several GLI inhibitors and their anti-tumor effects in vivo and in vitro.At present,there are only three GLI inhibitors participated in the clinical trials from different types of cancer,more clinical trials should be performed in the future urgently to verify the clinical efficacy of targeting GLI therapy.

关 键 词：肿瘤 HEDGEHOG信号通路 GLI GLI抑制剂 

分 类 号：R73-3[医药卫生—肿瘤]