Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas  

作　　者：Qin-Fen Chen Xiao-Dong Zhou Dan-Hong Fang En-Guang Zhang Chun-Jing Lin Xiao-Zhen Feng Na Wang Jian-Sheng Wu Dan Wang Wei-Hong Lin 

机构地区：[1]Department of Physical Examination Medical Care Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang Province,China [2]Department of Cardiovascular Medicine,The Key Laboratory of Cardiovascular Diseases of Wenzhou,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang Province,China

出　　处：《World Journal of Gastroenterology》2020年第37期5682-5692,共11页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND The significance of Helicobacter pylori(H.pylori)infection and atrophic gastritis(AG)in the prevalence of colorectal adenomas has been examined in a limited number of studies.However,these studies reported disputed conclusions.AIM To investigate whether H.pylori infection,AG,and H.pylori-related AG increase the risk of colorectal adenomas.METHODS This retrospective cross-sectional study included 6018 health-check individuals.The relevant data for physical examination,laboratory testing,13C-urea breath testing,gastroscopy,colonoscopy and histopathological examination of gastric and colorectal biopsies were recorded.Univariate and multivariate logistic regression analyses were performed to determine the association between H.pylori-related AG and colorectal adenomas.RESULTS Overall,1012 subjects(16.8%)were diagnosed with colorectal adenomas,of whom 143(2.4%)had advanced adenomas.Among the enrolled patients,the prevalence of H.pylori infection and AG was observed as 49.5%(2981/6018)and 10.0%(602/6018),respectively.Subjects with H.pylori infection had an elevated risk of colorectal adenomas(adjusted odds ratio[OR]of 1.220,95%confidence interval(CI):1.053-1.413,P=0.008)but no increased risk of advance adenomas(adjusted OR=1.303,95%CI:0.922-1.842,P=0.134).AG was significantly correlated to an increased risk of colorectal adenomas(unadjusted OR=1.668,95%CI:1.352-2.059,P<0.001;adjusted OR=1.237,95%CI:0.988-1.549,P=0.064).H.pylori infection accompanied by AG was significantly associated with an increased risk of adenomas(adjusted OR=1.491,95%CI:1.103-2.015,P=0.009)and advanced adenomas(adjusted OR=1.910,95%CI:1.022-3.572,P=0.043).CONCLUSION H.pylori-related AG was associated with a high risk of colorectal adenomas and advanced adenomas in Chinese individuals.

关 键 词：Helicobacter pylori GASTRITIS ATROPHY ADENOMAS COLORECTAL Health-check 

分 类 号：R573.3[医药卫生—消化系统] R735.34[医药卫生—内科学]